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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Critical Roles for LIGHT and Its Receptors in Generating T Cell-Mediated Immunity during Leishmania donovani Infection
|
|---|---|
| Published in |
PLoS Pathogens, October 2011
|
| DOI | 10.1371/journal.ppat.1002279 |
| Pubmed ID | |
| Authors |
Amanda C. Stanley, Fabian de Labastida Rivera, Ashraful Haque, Meru Sheel, Yonghong Zhou, Fiona H. Amante, Patrick T. Bunn, Louise M. Randall, Klaus Pfeffer, Stefanie Scheu, Michael J. Hickey, Bernadette M. Saunders, Carl Ware, Geoff R. Hill, Koji Tamada, Paul M. Kaye, Christian R. Engwerda |
| Abstract |
LIGHT (TNFSF14) is a member of the TNF superfamily involved in inflammation and defence against infection. LIGHT signals via two cell-bound receptors; herpes virus entry mediator (HVEM) and lymphotoxin-beta receptor (LTβR). We found that LIGHT is critical for control of hepatic parasite growth in mice with visceral leishmaniasis (VL) caused by infection with the protozoan parasite Leishmania donovani. LIGHT-HVEM signalling is essential for early dendritic cell IL-12/IL-23p40 production, and the generation of IFNγ- and TNF-producing T cells that control hepatic infection. However, we also discovered that LIGHT-LTβR interactions suppress anti-parasitic immunity in the liver in the first 7 days of infection by mechanisms that restrict both CD4(+) T cell function and TNF-dependent microbicidal mechanisms. Thus, we have identified distinct roles for LIGHT in infection, and show that manipulation of interactions between LIGHT and its receptors may be used for therapeutic advantage. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Brazil | 1 | 2% |
| Unknown | 40 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 24% |
| Student > Ph. D. Student | 9 | 21% |
| Student > Master | 4 | 10% |
| Professor > Associate Professor | 3 | 7% |
| Student > Bachelor | 3 | 7% |
| Other | 4 | 10% |
| Unknown | 9 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 38% |
| Biochemistry, Genetics and Molecular Biology | 5 | 12% |
| Immunology and Microbiology | 5 | 12% |
| Medicine and Dentistry | 3 | 7% |
| Arts and Humanities | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 11 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 October 2011.
All research outputs
#20,970,494
of 25,756,911 outputs
Outputs from PLoS Pathogens
#8,761
of 9,544 outputs
Outputs of similar age
#123,043
of 146,830 outputs
Outputs of similar age from PLoS Pathogens
#144
of 167 outputs
Altmetric has tracked 25,756,911 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,544 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.3. This one is in the 3rd percentile – i.e., 3% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 146,830 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 167 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.