| Title |
Vitamin A and D in allergy: from experimental animal models and cellular studies to human disease
|
|---|---|
| Published in |
Allergo Journal International, February 2018
|
| DOI | 10.1007/s40629-018-0054-2 |
| Pubmed ID | |
| Authors |
Karin Hufnagl, Erika Jensen-Jarolim |
| Abstract |
Vitamins A and D are able to modulate innate and adaptive immune responses and may therefore influence the development and the course of allergic diseases. This article reviews the current evidence for the experimental effects of vitamins A and D in vivo in animal models and on immune cells in vitro, and discusses their translational implication. A systematic literature search over the last 10 years was performed using MEDLINE and PubMed databases. Deficiencies of vitamin A or vitamin D in mouse models of allergic asthma seem to exacerbate allergic symptoms along with enhanced lung inflammation and Th2 cytokine production. In contrast, supplementation regimes especially with vitamin D were able to attenuate symptoms in therapeutic mouse models. The active metabolites retinoic acid (RA) and 1,25-dihydroxyvitamin D3 (VD3) induced tolerogenic dendritic cells (DCs) and up-regulated T‑regulatory cells in the allergic sensitization phase, which likely contributes to tolerance induction. Additionally, RA and VD3 maintained the stability of eosinophils and mast cells in the effector phase, thereby reducing allergic mediator release. Thus, both active vitamin metabolites RA and VD3 are able to influence allergic immune responses at several immunological sites. Animal studies predict that vitamin A and D may also be attractive players in the control of allergy in humans. Whether these experimental observations can be translated to the human situation remains open, as results from clinical trials are controversial. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 62 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 9 | 15% |
| Student > Ph. D. Student | 8 | 13% |
| Student > Bachelor | 6 | 10% |
| Researcher | 6 | 10% |
| Other | 5 | 8% |
| Other | 5 | 8% |
| Unknown | 23 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 15% |
| Biochemistry, Genetics and Molecular Biology | 6 | 10% |
| Immunology and Microbiology | 5 | 8% |
| Nursing and Health Professions | 5 | 8% |
| Agricultural and Biological Sciences | 3 | 5% |
| Other | 8 | 13% |
| Unknown | 26 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2018.
All research outputs
#16,002,613
of 25,760,414 outputs
Outputs from Allergo Journal International
#82
of 126 outputs
Outputs of similar age
#194,414
of 345,471 outputs
Outputs of similar age from Allergo Journal International
#2
of 4 outputs
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So far Altmetric has tracked 126 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
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