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Cancer Biology and Advances in Treatment

Overview of attention for book
Cover of 'Cancer Biology and Advances in Treatment'

Table of Contents

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    Book Overview
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    Chapter 147 The BRCA1 and BRCA2 Genes in Early-Onset Breast Cancer Patients
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    Chapter 148 Anti-cancer Effect of Xao Tam Phan Paramignya trimera Methanol Root Extract on Human Breast Cancer Cell Line MCF-7 in 3D Model
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    Chapter 300 A Novel Nonsense Mutation c.374C>G in CYP21A2 Gene of a Vietnamese Patient with Congenital Adrenal Hyperplasia
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    Chapter 301 Variation of Mitochondrial DNA HV1 AND HV2 of the Vietnamese Population
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    Chapter 302 Synthesis and Characterization of PLGA-PEG Thymoquinone Nanoparticles and Its Cytotoxicity Effects in Tamoxifen-Resistant Breast Cancer Cells
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    Chapter 464 Adipose-Derived Mesenchymal Stem Cells Promote Growth and Migration of Lung Adenocarcinoma Cancer Cells
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    Chapter 521 Predictive Potential of PD-L1, TYMS, and DCC Expressions in Treatment Outcome of Colorectal Carcinoma
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    Chapter 522 Clinical Trials with Cytokine-Induced Killer Cells and CAR-T Cell Transplantation for Non-small Cell Lung Cancer Treatment
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    Chapter 523 Isopanduratin A Isolated from Boesenbergia pandurata Reduces HepG2 Hepatocellular Carcinoma Cell Proliferation in Both Monolayer and Three-Dimensional Cultures
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    Chapter 524 Hopea odorata Extract Can Efficiently Kill Breast Cancer Cells and Cancer Stem-Like Cells in Three-Dimensional Culture More Than in Monolayer Cell Culture
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    Chapter 525 Selective Cytotoxicity of Some Plant Extracts Against Hepatocellular Carcinoma Cells but Not Mesenchymal Stem Cells: A Pilot Screening
Attention for Chapter 148: Anti-cancer Effect of Xao Tam Phan Paramignya trimera Methanol Root Extract on Human Breast Cancer Cell Line MCF-7 in 3D Model
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Chapter title
Anti-cancer Effect of Xao Tam Phan Paramignya trimera Methanol Root Extract on Human Breast Cancer Cell Line MCF-7 in 3D Model
Chapter number 148
Book title
Cancer Biology and Advances in Treatment
Published in
Advances in experimental medicine and biology, January 2018
DOI 10.1007/5584_2018_148
Pubmed ID
Book ISBNs
978-3-03-057253-2, 978-3-03-057254-9
Authors

Lam-Huyen Nguyen-Thi, Sinh Truong Nguyen, Thao Phuong Tran, Chinh-Nhan Phan-Lu, Trung The Van, Phuc Van Pham, Nguyen-Thi, Lam-Huyen, Nguyen, Sinh Truong, Tran, Thao Phuong, Phan-Lu, Chinh-Nhan, Van Pham, Phuc, The Van, Trung

Abstract

Cancer is one of the leading causes of death in the world. A great deal of effort has been made to discover new agents for cancer treatment. Xao tam phan (Paramignya trimera) is a traditional medicine of Vietnam used in cancer treatment for a long time, yet there is not much scientific evidence proving its anticancer potency. The study aimed to evaluate the toxicity of Paramignya trimera extract (PTE) on multicellular tumor spheres (MCTS) of MCF-7 cells using hanging drop technique. Firstly, MCF-7 cells were seeded on hanging drop plates, spheroid size was tracked, and growth curve was measured by MTT assay and AlamarBlue® assay. The necrotic core of MCTS was evaluated by propidium iodide (PI) staining. Toxicity of doxorubicin (DOX) and tirapazamine (TPZ) was then tested on 3D model compared to 2D culture condition. The results showed that the IC50 of DOX on 3D MCF-7 cells was nearly 50 times greater than monolayer MCF-7 cells. In contrast, TPZ (an agent which is specifically toxic under hypoxic conditions) had significantly lower IC50 in 3D condition than in 2D. The toxicity tests for PTE showed that PTE strongly inhibited MCF-7 cells in both 2D and 3D conditions. Interestingly, the IC50 of PTE in 3D model was remarkably lower than in 2D (IC50 value was 168.9 ± 11.65 μg/ml compared to 260.8 ± 16.54 μg/ml, respectively). The invasion assay showed that PTE completely inhibited invasion of MCF-7 cells at 250 μg/mL concentration. Also, flow cytometry results indicated that PTE effectively induced apoptosis in MCF-7 spheroids in 3D condition at 250 μg/mL concentration. The results from this study emphasize the promise of PTE in cancer therapy.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 20%
Lecturer 1 7%
Student > Master 1 7%
Researcher 1 7%
Student > Postgraduate 1 7%
Other 0 0%
Unknown 8 53%
Readers by discipline Count As %
Medicine and Dentistry 3 20%
Agricultural and Biological Sciences 2 13%
Biochemistry, Genetics and Molecular Biology 1 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 7%
Nursing and Health Professions 1 7%
Other 0 0%
Unknown 7 47%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 May 2018.
All research outputs
#18,604,390
of 23,045,021 outputs
Outputs from Advances in experimental medicine and biology
#3,329
of 4,971 outputs
Outputs of similar age
#330,638
of 442,426 outputs
Outputs of similar age from Advances in experimental medicine and biology
#154
of 237 outputs
Altmetric has tracked 23,045,021 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,971 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 442,426 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 237 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.