Title |
99mTc-HMDP scintigraphy rectifies wrong diagnosis of AL amyloidosis
|
---|---|
Published in |
Journal of Nuclear Cardiology, May 2015
|
DOI | 10.1007/s12350-015-0176-6 |
Pubmed ID | |
Authors |
Arnault Galat, Axel Van Der Gucht, Magali Colombat, David Attias, Emmanuel Itti, Michel Meignan, Fabien Lebras, Valérie Molinier-Frenkel, Nicole Benhaiem, Aziz Guellich, Jean Rosso, Thibaud Damy |
Abstract |
A 71-year-old African man without history of cardiac disease was referred to our center for dyspnea. Transthoracic echocardiogram and cardiac MRI were suggestive of cardiac amyloidosis (CA). The diagnosis of the light-chain cardiac amyloidosis (AL-CA) was made after a first endomyocardial biopsy. Accordingly chemotherapy was started. Systematic 99mTc-HMDP scintigraphy showed moderate cardiac uptake (visual score of 2), unusual for AL-CA, and permitted to rectify the diagnosis. Hereditary transthyretin cardiac amyloidosis was confirmed by a second endomyocardial biopsy with a positive Congo-red and anti-transthyretin antibody stainings, mass spectrometry and genetic analysis (Val122Ile mutation). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 67% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 12 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 4 | 33% |
Lecturer > Senior Lecturer | 1 | 8% |
Student > Bachelor | 1 | 8% |
Student > Doctoral Student | 1 | 8% |
Professor | 1 | 8% |
Other | 1 | 8% |
Unknown | 3 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Social Sciences | 2 | 17% |
Medicine and Dentistry | 2 | 17% |
Economics, Econometrics and Finance | 1 | 8% |
Chemical Engineering | 1 | 8% |
Biochemistry, Genetics and Molecular Biology | 1 | 8% |
Other | 1 | 8% |
Unknown | 4 | 33% |