Title |
miR-582-5p inhibits proliferation of hepatocellular carcinoma by targeting CDK1 and AKT3
|
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Published in |
Tumor Biology, May 2015
|
DOI | 10.1007/s13277-015-3582-0 |
Pubmed ID | |
Authors |
Yi Zhang, Wei Huang, Yan Ran, Yan Xiong, Zibiao Zhong, Xiaoli Fan, Zhenghua Wang, Qifa Ye |
Abstract |
microRNAs play an important role in the progression of hepatocellular carcinoma (HCC). In this study, we found that miR-582-5p expression was downregulated in hepatoma tissues and HCC cell lines. Upregulation of miR-582-5p reduced colony number, inhibited cellular proliferation, and arrested cell cycle in G0/G1 phase. When miR-582-5p was inhibited, the colony number was increased and cellular proliferation and cell cycle were promoted. Further studies showed that miR-582-5p regulated the progression of HCC through directly inhibiting the expression of CDK1 and AKT3, and indirectly inhibiting the expression of cyclinD1. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 6 | 30% |
Researcher | 5 | 25% |
Other | 2 | 10% |
Student > Ph. D. Student | 2 | 10% |
Student > Doctoral Student | 2 | 10% |
Other | 2 | 10% |
Unknown | 1 | 5% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 7 | 35% |
Biochemistry, Genetics and Molecular Biology | 4 | 20% |
Medicine and Dentistry | 4 | 20% |
Immunology and Microbiology | 2 | 10% |
Chemical Engineering | 1 | 5% |
Other | 0 | 0% |
Unknown | 2 | 10% |