| Title |
The precision of textural analysis in 18F-FDG-PET scans of oesophageal cancer
|
|---|---|
| Published in |
European Radiology, May 2015
|
| DOI | 10.1007/s00330-015-3681-8 |
| Pubmed ID | |
| Authors |
Georgia Doumou, Musib Siddique, Charalampos Tsoumpas, Vicky Goh, Gary J. Cook |
| Abstract |
Measuring tumour heterogeneity by textural analysis in (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) provides predictive and prognostic information but technical aspects of image processing can influence parameter measurements. We therefore tested effects of image smoothing, segmentation and quantisation on the precision of heterogeneity measurements. Sixty-four (18)F-FDG PET/CT images of oesophageal cancer were processed using different Gaussian smoothing levels (2.0, 2.5, 3.0, 3.5, 4.0 mm), maximum standardised uptake value (SUVmax) segmentation thresholds (45 %, 50 %, 55 %, 60 %) and quantisation (8, 16, 32, 64, 128 bin widths). Heterogeneity parameters included grey-level co-occurrence matrix (GLCM), grey-level run length matrix (GLRL), neighbourhood grey-tone difference matrix (NGTDM), grey-level size zone matrix (GLSZM) and fractal analysis methods. The concordance correlation coefficient (CCC) for the three processing variables was calculated for each heterogeneity parameter. Most parameters showed poor agreement between different bin widths (CCC median 0.08, range 0.004-0.99). Segmentation and smoothing showed smaller effects on precision (segmentation: CCC median 0.82, range 0.33-0.97; smoothing: CCC median 0.99, range 0.58-0.99). Smoothing and segmentation have only a small effect on the precision of heterogeneity measurements in (18)F-FDG PET data. However, quantisation often has larger effects, highlighting a need for further evaluation and standardisation of parameters for multicentre studies. • Heterogeneity measurement precision in (18) F-FDG PET is influenced by image processing methods. • Quantisation shows large effects on precision of heterogeneity parameters in (18) F-FDG PET/CT. • Smoothing and segmentation show comparatively smaller effects on precision of heterogeneity parameters. |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 1% |
| France | 1 | 1% |
| Unknown | 69 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 18% |
| Researcher | 13 | 18% |
| Student > Master | 9 | 13% |
| Student > Doctoral Student | 7 | 10% |
| Student > Bachelor | 3 | 4% |
| Other | 12 | 17% |
| Unknown | 14 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 29 | 41% |
| Engineering | 9 | 13% |
| Computer Science | 3 | 4% |
| Nursing and Health Professions | 3 | 4% |
| Physics and Astronomy | 3 | 4% |
| Other | 6 | 8% |
| Unknown | 18 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 May 2015.
All research outputs
#20,274,720
of 22,807,037 outputs
Outputs from European Radiology
#3,295
of 4,115 outputs
Outputs of similar age
#223,312
of 266,745 outputs
Outputs of similar age from European Radiology
#56
of 73 outputs
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