Title |
Fluoxetine is Neuroprotective in Early Brain Injury via its Anti-inflammatory and Anti-apoptotic Effects in a Rat Experimental Subarachnoid Hemorrhage Model
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Published in |
Neuroscience Bulletin, April 2018
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DOI | 10.1007/s12264-018-0232-8 |
Pubmed ID | |
Authors |
Hui-Min Hu, Bin Li, Xiao-Dong Wang, Yun-Shan Guo, Hua Hui, Hai-Ping Zhang, Biao Wang, Da-Geng Huang, Ding-Jun Hao |
Abstract |
Fluoxetine, an anti-depressant drug, has recently been shown to provide neuroprotection in central nervous system injury, but its roles in subarachnoid hemorrhage (SAH) remain unclear. In this study, we aimed to evaluate whether fluoxetine attenuates early brain injury (EBI) after SAH. We demonstrated that intraperitoneal injection of fluoxetine (10 mg/kg per day) significantly attenuated brain edema and blood-brain barrier (BBB) disruption, microglial activation, and neuronal apoptosis in EBI after experimental SAH, as evidenced by the reduction of brain water content and Evans blue dye extravasation, prevention of disruption of the tight junction proteins zonula occludens-1, claudin-5, and occludin, a decrease of cells staining positive for Iba-1, ED-1, and TUNEL and a decline in IL-1β, IL-6, TNF-α, MDA, 3-nitrotyrosine, and 8-OHDG levels. Moreover, fluoxetine significantly improved the neurological deficits of EBI and long-term sensorimotor behavioral deficits following SAH in a rat model. These results indicated that fluoxetine has a neuroprotective effect after experimental SAH. |
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Unknown | 1 | 100% |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 22 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Doctoral Student | 4 | 18% |
Researcher | 3 | 14% |
Student > Master | 3 | 14% |
Student > Ph. D. Student | 2 | 9% |
Student > Bachelor | 1 | 5% |
Other | 0 | 0% |
Unknown | 9 | 41% |
Readers by discipline | Count | As % |
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Neuroscience | 3 | 14% |
Business, Management and Accounting | 1 | 5% |
Nursing and Health Professions | 1 | 5% |
Immunology and Microbiology | 1 | 5% |
Other | 3 | 14% |
Unknown | 10 | 45% |