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X Demographics
Mendeley readers
Attention Score in Context
| Title |
De novo assembly of a haplotype-resolved human genome
|
|---|---|
| Published in |
Nature Biotechnology, May 2015
|
| DOI | 10.1038/nbt.3200 |
| Pubmed ID | |
| Authors |
Hongzhi Cao, Honglong Wu, Ruibang Luo, Shujia Huang, Yuhui Sun, Xin Tong, Yinlong Xie, Binghang Liu, Hailong Yang, Hancheng Zheng, Jian Li, Bo Li, Yu Wang, Fang Yang, Peng Sun, Siyang Liu, Peng Gao, Haodong Huang, Jing Sun, Dan Chen, Guangzhu He, Weihua Huang, Zheng Huang, Yue Li, Laurent C A M Tellier, Xiao Liu, Qiang Feng, Xun Xu, Xiuqing Zhang, Lars Bolund, Anders Krogh, Karsten Kristiansen, Radoje Drmanac, Snezana Drmanac, Rasmus Nielsen, Songgang Li, Jian Wang, Huanming Yang, Yingrui Li, Gane Ka-Shu Wong, Jun Wang |
| Abstract |
The human genome is diploid, and knowledge of the variants on each chromosome is important for the interpretation of genomic information. Here we report the assembly of a haplotype-resolved diploid genome without using a reference genome. Our pipeline relies on fosmid pooling together with whole-genome shotgun strategies, based solely on next-generation sequencing and hierarchical assembly methods. We applied our sequencing method to the genome of an Asian individual and generated a 5.15-Gb assembled genome with a haplotype N50 of 484 kb. Our analysis identified previously undetected indels and 7.49 Mb of novel coding sequences that could not be aligned to the human reference genome, which include at least six predicted genes. This haplotype-resolved genome represents the most complete de novo human genome assembly to date. Application of our approach to identify individual haplotype differences should aid in translating genotypes to phenotypes for the development of personalized medicine. |
X Demographics
The data shown below were collected from the profiles of 136 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 39 | 29% |
| United Kingdom | 12 | 9% |
| India | 4 | 3% |
| France | 4 | 3% |
| Germany | 4 | 3% |
| Netherlands | 3 | 2% |
| Spain | 3 | 2% |
| Finland | 2 | 1% |
| Thailand | 1 | <1% |
| Other | 14 | 10% |
| Unknown | 50 | 37% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 67 | 49% |
| Members of the public | 63 | 46% |
| Science communicators (journalists, bloggers, editors) | 3 | 2% |
| Practitioners (doctors, other healthcare professionals) | 3 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 238 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 2% |
| France | 2 | <1% |
| Netherlands | 2 | <1% |
| Spain | 2 | <1% |
| United Kingdom | 2 | <1% |
| Portugal | 1 | <1% |
| Canada | 1 | <1% |
| New Zealand | 1 | <1% |
| Switzerland | 1 | <1% |
| Other | 4 | 2% |
| Unknown | 217 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 57 | 24% |
| Student > Ph. D. Student | 54 | 23% |
| Other | 22 | 9% |
| Student > Master | 22 | 9% |
| Student > Bachelor | 13 | 5% |
| Other | 37 | 16% |
| Unknown | 33 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 93 | 39% |
| Biochemistry, Genetics and Molecular Biology | 66 | 28% |
| Computer Science | 15 | 6% |
| Medicine and Dentistry | 5 | 2% |
| Neuroscience | 4 | 2% |
| Other | 14 | 6% |
| Unknown | 41 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 130. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 February 2020.
All research outputs
#316,568
of 25,284,710 outputs
Outputs from Nature Biotechnology
#737
of 8,784 outputs
Outputs of similar age
#3,283
of 273,560 outputs
Outputs of similar age from Nature Biotechnology
#7
of 107 outputs
Altmetric has tracked 25,284,710 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,784 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.0. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 273,560 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 107 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.