| Title |
Contrast-enhanced MRI features in the early diagnosis of Juvenile Idiopathic Arthritis
|
|---|---|
| Published in |
European Radiology, May 2015
|
| DOI | 10.1007/s00330-015-3752-x |
| Pubmed ID | |
| Authors |
Robert Hemke, Taco W. Kuijpers, Charlotte M. Nusman, Dieneke Schonenberg-Meinema, Marion A. J. van Rossum, Koert M. Dolman, J. Merlijn van den Berg, Mario Maas |
| Abstract |
To determine whether clinical, laboratory or Magnetic Resonance Imaging (MRI) measures differentiate Juvenile Idiopathic Arthritis (JIA) from other forms of active childhood arthritis. We prospectively collected data of 80 treatment-naïve patients clinically suspected of JIA with active non-infectious arthritis of (at least) one knee for <12 months duration. Upon presentation patients underwent clinical and laboratory assessments and contrast-enhanced MRI. MRI was not used as a diagnostic criterion. Forty-four (55 %) patients were clinically diagnosed with JIA, whereas in 36 (45 %) patients the diagnosis of JIA was discarded on clinical or laboratory findings. MRI-based synovitis was present in 27 (61.4 %) JIA patients and in 7 (19.4 %) non-JIA patients (P < 0.001). Five factors (male gender, physician's global assessment of overall disease activity, joints with limited range of motion, HLA-B27, MRI-based synovitis) were associated with the onset of JIA. In multivariate analysis MRI-based synovitis proved to be independently associated with JIA (OR 6.58, 95 % CI 2.36-18.33). In patients with MRI-based synovitis, the RR of having JIA was 3.16 (95 % CI 1.6-6.4). The presence of MRI-based synovitis is associated with the clinical onset of JIA. Physical examination could be supported by MRI, particularly to contribute in the early differentiation of different forms of non-infectious childhood arthritis. • Juvenile Idiopathic Arthritis (JIA) is a diagnosis of exclusion. • Differentiating JIA and other forms of childhood arthritis can be difficult. • MRI-techniques have substantially improved evaluation of joint abnormalities in JIA patients. • MRI-based synovitis is significantly associated with the clinical onset of JIA. • MRI could support physical examination in the early differentiation of childhood arthritis. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 2% |
| Egypt | 1 | 2% |
| Unknown | 52 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 8 | 15% |
| Researcher | 8 | 15% |
| Student > Bachelor | 8 | 15% |
| Student > Doctoral Student | 5 | 9% |
| Student > Ph. D. Student | 4 | 7% |
| Other | 13 | 24% |
| Unknown | 8 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 35 | 65% |
| Nursing and Health Professions | 2 | 4% |
| Engineering | 2 | 4% |
| Computer Science | 1 | 2% |
| Immunology and Microbiology | 1 | 2% |
| Other | 4 | 7% |
| Unknown | 9 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 May 2015.
All research outputs
#17,758,791
of 22,807,037 outputs
Outputs from European Radiology
#2,789
of 4,115 outputs
Outputs of similar age
#180,815
of 267,813 outputs
Outputs of similar age from European Radiology
#47
of 73 outputs
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