| Title |
A single charge in the actin binding domain of fascin can independently tune the linear and non-linear response of an actin bundle network
|
|---|---|
| Published in |
The European Physical Journal E, May 2015
|
| DOI | 10.1140/epje/i2015-15050-3 |
| Pubmed ID | |
| Authors |
M. Maier, K. W. Müller, C. Heussinger, S. Köhler, W. A. Wall, A. R. Bausch, O. Lieleg |
| Abstract |
Actin binding proteins (ABPs) not only set the structure of actin filament assemblies but also mediate the frequency-dependent viscoelastic moduli of cross-linked and bundled actin networks. Point mutations in the actin binding domain of those ABPs can tune the association and dissociation dynamics of the actin/ABP bond and thus modulate the network mechanics both in the linear and non-linear response regime. We here demonstrate how the exchange of a single charged amino acid in the actin binding domain of the ABP fascin triggers such a modulation of the network rheology. Whereas the overall structure of the bundle networks is conserved, the transition point from strain-hardening to strain-weakening sensitively depends on the cross-linker off-rate and the applied shear rate. Our experimental results are consistent both with numerical simulations of a cross-linked bundle network and a theoretical description of the bundle network mechanics which is based on non-affine bending deformations and force-dependent cross-link dynamics. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 6% |
| Unknown | 17 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 28% |
| Student > Ph. D. Student | 4 | 22% |
| Professor | 2 | 11% |
| Student > Master | 2 | 11% |
| Student > Doctoral Student | 1 | 6% |
| Other | 1 | 6% |
| Unknown | 3 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Physics and Astronomy | 10 | 56% |
| Biochemistry, Genetics and Molecular Biology | 2 | 11% |
| Engineering | 2 | 11% |
| Agricultural and Biological Sciences | 1 | 6% |
| Unknown | 3 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 February 2016.
All research outputs
#20,879,072
of 23,498,099 outputs
Outputs from The European Physical Journal E
#560
of 650 outputs
Outputs of similar age
#224,699
of 268,143 outputs
Outputs of similar age from The European Physical Journal E
#12
of 14 outputs
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