| Title |
Exposure to radiation therapy is associated with female reproductive health among childhood cancer survivors: a meta-analysis study
|
|---|---|
| Published in |
Journal of Assisted Reproduction and Genetics, May 2015
|
| DOI | 10.1007/s10815-015-0490-6 |
| Pubmed ID | |
| Authors |
Wei Gao, Jin-Xiao Liang, Qiu Yan |
| Abstract |
Many epidemiological studies have revealed a positive correlation between medical radiation exposure and the reproductive health in female childhood cancer survivors. However, because of variations in the samples size, such studies showed partly inconsistent conclusions. The aim of this meta-analysis was to clarify the association between radiotherapy and the risk of reproductive health impairment for female who survived from childhood cancer. Fourteen cohort studies involving childhood radiotherapy were selected as the exposure of interest and the impaired reproductive health condition during the childbearing age as the outcome. Among meta-analysis of observational studies found in Pubmed and Embase from 1900 to 2014, we evaluated those relevant observational studies which surveyed the association of medical radiation and reproductive health in female childhood cancer survivors. Review Manager 5.2 and STATA 12.0 software were used to perform the meta-analysis. Study-specific estimations for each outcome were combined into a pooled relative risk (RR) with 95 % confidence interval (CI) by a meta-analytic approach. Based on a random-effects meta-analysis, significant association between infertility (RR = 1.28, 95 % CI = 1.16-1.42), acute ovarian failure (AOF) (RR = 9.51, 95 % CI = 5.03-17.96), low level of anti mullerian hormone (AMH) (<1 ng/mL) (RR = 14.79, 95 % CI = 3.36-66.64), stillbirth (RR = 1.19, 95 % CI = 1.02-1.39) and low birth weight (RR = 2.22, 95 % CI = 1.55-3.17) were identified. Conversely, no significant results were found in abortion and congenital malformations. To the best of our knowledge, this is the first meta-analysis assessing the effect of medical radiation on female childhood cancer survivors' reproductive capability and pregnancy outcomes. Although there were some limitations, our meta-analysis further supported that radiotherapy was a risk factor for reproductive health problems of female who survived from childhood cancer. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ethiopia | 1 | 2% |
| Unknown | 60 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 9 | 15% |
| Student > Ph. D. Student | 9 | 15% |
| Student > Bachelor | 6 | 10% |
| Lecturer | 4 | 7% |
| Researcher | 4 | 7% |
| Other | 12 | 20% |
| Unknown | 17 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 23 | 38% |
| Agricultural and Biological Sciences | 4 | 7% |
| Nursing and Health Professions | 4 | 7% |
| Unspecified | 3 | 5% |
| Biochemistry, Genetics and Molecular Biology | 1 | 2% |
| Other | 8 | 13% |
| Unknown | 18 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 May 2015.
All research outputs
#19,611,252
of 24,119,703 outputs
Outputs from Journal of Assisted Reproduction and Genetics
#1,199
of 1,697 outputs
Outputs of similar age
#197,840
of 268,442 outputs
Outputs of similar age from Journal of Assisted Reproduction and Genetics
#10
of 19 outputs
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