| Title |
Nitrosative Stress as a Modulator of Inflammatory Change in a Model of Takotsubo Syndrome
|
|---|---|
| Published in |
JACC: Basic to Translational Science, April 2018
|
| DOI | 10.1016/j.jacbts.2017.10.002 |
| Pubmed ID | |
| Authors |
Sven Y. Surikow, Thanh H. Nguyen, Irene Stafford, Matthew Chapman, Sujith Chacko, Kuljit Singh, Giovanni Licari, Betty Raman, Darren J. Kelly, Yuan Zhang, Mark T. Waddingham, Doan T. Ngo, Alexander P. Bate, Su Jen Chua, Michael P. Frenneaux, John D. Horowitz |
| Abstract |
Previous studies have shown that patients with Takotsubo syndrome (TS) have supranormal nitric oxide signaling, and post-mortem studies of TS heart samples revealed nitrosative stress. Therefore, we first showed in a female rat model that isoproterenol induces TS-like echocardiographic changes, evidence of nitrosative stress, and consequent activation of the energy-depleting enzyme poly(ADP-ribose) polymerase-1. We subsequently showed that pre-treatment with an inhibitor of poly(ADP-ribose) polymerase-1 ameliorated contractile abnormalities. These findings thus add to previous reports of aberrant β-adrenoceptor signaling (coupled with nitric oxide synthase activation) to elucidate mechanisms of impaired cardiac function in TS and point to potential methods of treatment. |
X Demographics
The data shown below were collected from the profiles of 26 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 15% |
| United Kingdom | 4 | 15% |
| Colombia | 1 | 4% |
| Mexico | 1 | 4% |
| Chile | 1 | 4% |
| Venezuela, Bolivarian Republic of | 1 | 4% |
| Nigeria | 1 | 4% |
| Peru | 1 | 4% |
| Australia | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 10 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 19 | 73% |
| Scientists | 4 | 15% |
| Science communicators (journalists, bloggers, editors) | 2 | 8% |
| Practitioners (doctors, other healthcare professionals) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 34 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 12% |
| Student > Ph. D. Student | 4 | 12% |
| Student > Doctoral Student | 3 | 9% |
| Professor | 3 | 9% |
| Other | 3 | 9% |
| Other | 6 | 18% |
| Unknown | 11 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 32% |
| Biochemistry, Genetics and Molecular Biology | 5 | 15% |
| Chemistry | 2 | 6% |
| Immunology and Microbiology | 1 | 3% |
| Social Sciences | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 13 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 May 2018.
All research outputs
#2,626,015
of 25,559,053 outputs
Outputs from JACC: Basic to Translational Science
#224
of 809 outputs
Outputs of similar age
#53,074
of 341,196 outputs
Outputs of similar age from JACC: Basic to Translational Science
#7
of 19 outputs
Altmetric has tracked 25,559,053 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 809 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.3. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,196 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.