| Title |
Aggressive B cell lymphomas of the gastrointestinal tract: clinicopathologic and genetic analysis
|
|---|---|
| Published in |
Virchows Archiv, October 2011
|
| DOI | 10.1007/s00428-011-1153-3 |
| Pubmed ID | |
| Authors |
Song-Yi Choi, Seok Jin Kim, Won Seog Kim, Kihyun Kim, Young-Hyeh Ko |
| Abstract |
Aggressive B cell lymphomas of the gastrointestinal tract include Burkitt lymphoma (BL), diffuse large B cell lymphoma, and B cell lymphoma, unclassifiable, with features intermediate between DLBCL and BL. To investigate the clinical characters of DLBCL/BL of the gastrointestinal (GI) tract, 101 cases of aggressive B cell lymphoma of the GI tract were analyzed by immunohistochemistry and fluorescence in situ hybridization (FISH) using break apart probe for c-MYC gene. For cases with c-MYC rearrangement, additional FISH studies with MYC/IgH fusion probe, BCL2 break apart probe, and BCL6 break apart probe were performed. MYC rearrangement was detected in 23 of 101 cases of aggressive B cell lymphomas (22.5%). The cases with MYC rearrangement were divided into 14 BL, three DLBCL/BL, and six DLBCL. One of the three DLBCL/BL had double translocation for MYC and BCL6 gene. Clinically, DLBCL/BL of the GI tract was more akin to Burkitt lymphoma than it is to GI tract DLBCL with c-MYC rearrangement. The overall prognosis of patients with DLBCL/BL was the worst among aggressive B cell lymphomas. DLBCL/BL is uncommon category of B cell lymphoma in the GI tract with aggressive clinical course despite of intensive chemotherapy. |
Mendeley readers
The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 16 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 3 | 19% |
| Professor | 2 | 13% |
| Student > Ph. D. Student | 2 | 13% |
| Researcher | 2 | 13% |
| Professor > Associate Professor | 2 | 13% |
| Other | 2 | 13% |
| Unknown | 3 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 50% |
| Agricultural and Biological Sciences | 3 | 19% |
| Chemistry | 1 | 6% |
| Biochemistry, Genetics and Molecular Biology | 1 | 6% |
| Unknown | 3 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2016.
All research outputs
#7,409,093
of 22,653,392 outputs
Outputs from Virchows Archiv
#409
of 1,934 outputs
Outputs of similar age
#46,119
of 136,716 outputs
Outputs of similar age from Virchows Archiv
#3
of 12 outputs
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