| Title |
Association of pyrethroid pesticide exposure with attention-deficit/hyperactivity disorder in a nationally representative sample of U.S. children
|
|---|---|
| Published in |
Environmental Health, May 2015
|
| DOI | 10.1186/s12940-015-0030-y |
| Pubmed ID | |
| Authors |
Melissa Wagner-Schuman, Jason R. Richardson, Peggy Auinger, Joseph M. Braun, Bruce P. Lanphear, Jeffery N. Epstein, Kimberly Yolton, Tanya E. Froehlich |
| Abstract |
Pyrethroid pesticides cause abnormalities in the dopamine system and produce an ADHD phenotype in animal models, with effects accentuated in males versus females. However, data regarding behavioral effects of pyrethroid exposure in children is limited. We examined the association between pyrethroid pesticide exposure and ADHD in a nationally representative sample of US children, and tested whether this association differs by sex. Data are from 8-15 year old participants (N = 687) in the 2001-2002 National Health and Nutrition Examination Survey. Exposure was assessed using concurrent urinary levels of the pyrethroid metabolite 3-phenoxybenzoic acid (3-PBA). ADHD was defined by either meeting Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition criteria on the Diagnostic Interview Schedule for Children (DISC) or caregiver report of a prior diagnosis. ADHD symptom counts were determined via the DISC. Multivariable logistic regression examined the link between pyrethroid exposure and ADHD, and poisson regression investigated the link between exposure and ADHD symptom counts. Children with urinary 3-PBA above the limit of detection (LOD) were twice as likely to have ADHD compared with those below the LOD (adjusted odds ratio [aOR] 2.42; 95 % confidence interval [CI] 1.06, 5.57). Hyperactive-impulsive symptoms increased by 50 % for every 10-fold increase in 3-PBA levels (adjusted count ratio 1.50; 95 % CI 1.03, 2.19); effects on inattention were not significant. We observed possible sex-specific effects: pyrethroid biomarkers were associated with increased odds of an ADHD diagnosis and number of ADHD symptoms for boys but not girls. We found an association between increasing pyrethroid pesticide exposure and ADHD which may be stronger for hyperactive-impulsive symptoms compared to inattention and in boys compared to girls. Given the growing use of pyrethroid pesticides, these results may be of considerable public health import. |
X Demographics
The data shown below were collected from the profiles of 41 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 22% |
| Japan | 4 | 10% |
| France | 3 | 7% |
| Spain | 3 | 7% |
| Canada | 3 | 7% |
| Germany | 2 | 5% |
| Colombia | 1 | 2% |
| Brazil | 1 | 2% |
| Unknown | 15 | 37% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 34 | 83% |
| Practitioners (doctors, other healthcare professionals) | 4 | 10% |
| Scientists | 2 | 5% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 90 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 5 | 6% |
| Student > Bachelor | 3 | 3% |
| Student > Doctoral Student | 3 | 3% |
| Researcher | 3 | 3% |
| Other | 2 | 2% |
| Other | 4 | 4% |
| Unknown | 70 | 78% |
| Readers by discipline | Count | As % |
|---|---|---|
| Nursing and Health Professions | 4 | 4% |
| Environmental Science | 3 | 3% |
| Arts and Humanities | 2 | 2% |
| Medicine and Dentistry | 2 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Other | 8 | 9% |
| Unknown | 69 | 77% |
Attention Score in Context
This research output has an Altmetric Attention Score of 185. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 June 2023.
All research outputs
#196,383
of 23,879,989 outputs
Outputs from Environmental Health
#69
of 1,543 outputs
Outputs of similar age
#2,086
of 269,584 outputs
Outputs of similar age from Environmental Health
#1
of 23 outputs
Altmetric has tracked 23,879,989 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,543 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 34.8. This one has done particularly well, scoring higher than 95% of its peers.
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We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.