| Title |
Increased Afterload Augments Sunitinib-Induced Cardiotoxicity in an Engineered Cardiac Microtissue Model
|
|---|---|
| Published in |
JACC: Basic to Translational Science, May 2018
|
| DOI | 10.1016/j.jacbts.2017.12.007 |
| Pubmed ID | |
| Authors |
Rachel Truitt, Anbin Mu, Elise A. Corbin, Alexia Vite, Jeffrey Brandimarto, Bonnie Ky, Kenneth B. Margulies |
| Abstract |
Sunitinib, a multitargeted oral tyrosine kinase inhibitor, used widely to treat solid tumors, results in hypertension in up to 47% and left ventricular dysfunction in up to 19% of treated individuals. The relative contribution of afterload toward inducing cardiac dysfunction with sunitinib treatment remains unknown. We created a preclinical model of sunitinib cardiotoxicity using engineered microtissues that exhibited cardiomyocyte death, decreases in force generation, and spontaneous beating at clinically relevant doses. Simulated increases in afterload augmented sunitinib cardiotoxicity in both rat and human microtissues, which suggest that antihypertensive therapy may be a strategy to prevent left ventricular dysfunction in patients treated with sunitinib. |
X Demographics
The data shown below were collected from the profiles of 49 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 19 | 39% |
| Brazil | 3 | 6% |
| Canada | 2 | 4% |
| Spain | 2 | 4% |
| Mexico | 1 | 2% |
| Peru | 1 | 2% |
| United Kingdom | 1 | 2% |
| Nigeria | 1 | 2% |
| India | 1 | 2% |
| Other | 6 | 12% |
| Unknown | 12 | 24% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 31 | 63% |
| Scientists | 9 | 18% |
| Practitioners (doctors, other healthcare professionals) | 8 | 16% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 80 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 29% |
| Researcher | 10 | 13% |
| Student > Postgraduate | 6 | 8% |
| Student > Doctoral Student | 6 | 8% |
| Student > Bachelor | 5 | 6% |
| Other | 14 | 18% |
| Unknown | 16 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 20 | 25% |
| Biochemistry, Genetics and Molecular Biology | 13 | 16% |
| Medicine and Dentistry | 13 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 6% |
| Agricultural and Biological Sciences | 4 | 5% |
| Other | 4 | 5% |
| Unknown | 21 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 August 2018.
All research outputs
#1,457,446
of 25,621,213 outputs
Outputs from JACC: Basic to Translational Science
#130
of 815 outputs
Outputs of similar age
#30,725
of 344,995 outputs
Outputs of similar age from JACC: Basic to Translational Science
#8
of 22 outputs
Altmetric has tracked 25,621,213 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 815 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.2. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 344,995 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.