| Title |
Development of fluorescent probes that bind and stain amyloid plaques in Alzheimer’s disease
|
|---|---|
| Published in |
Archives of Pharmacal Research, May 2015
|
| DOI | 10.1007/s12272-015-0617-4 |
| Pubmed ID | |
| Authors |
Seung-Jin Jung, Seung-Hwan Park, Eun Je Lee, Jeong Hoon Park, Young Bae Kong, Jong Kook Rho, Min Goo Hur, Seung Dae Yang, Yong Dae Park |
| Abstract |
β-amyloid (Aβ) plaques in the brain are composed of Aβ40 and Aβ42 peptides, and are the defining pathological feature of Alzheimer's disease (AD). Fluorescent probes that can detect Aβ plaques have gained increasing interest as potential tools for in vitro and in vivo monitoring of the progression of AD. In this study, chalcone-mimic fluorescent probe 5 was designed and prepared. Probe 5 exhibited an approximately 50-fold increase in emission intensity after mixing with Aβ42 aggregates, a high affinity for Aβ42 aggregates (K D = 1.59 μM), and reasonable lipophilicity (log P value = 2.55). Probe 5 also exhibited specific staining of Aβ plaques in the transgenic mice (APP/PS1) brain sections. Ex vivo fluorescence imaging of the brain from normal and TG mice revealed that probe 5 was able to penetrate the BBB and stain the Aβ plaques. These results suggest that chalcone-mimic probe 5 possessed the requirements of a fluorescent probe for Aβ plaques and may be useful in AD research. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 28 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 7 | 25% |
| Student > Ph. D. Student | 5 | 18% |
| Student > Master | 3 | 11% |
| Researcher | 2 | 7% |
| Student > Postgraduate | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 10 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 6 | 21% |
| Engineering | 2 | 7% |
| Biochemistry, Genetics and Molecular Biology | 2 | 7% |
| Arts and Humanities | 1 | 4% |
| Mathematics | 1 | 4% |
| Other | 6 | 21% |
| Unknown | 10 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 May 2015.
All research outputs
#2,939,613
of 22,807,037 outputs
Outputs from Archives of Pharmacal Research
#72
of 1,295 outputs
Outputs of similar age
#39,803
of 266,724 outputs
Outputs of similar age from Archives of Pharmacal Research
#1
of 13 outputs
Altmetric has tracked 22,807,037 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,295 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,724 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.