| Title |
UVA-photoprotective potential of silymarin and silybin
|
|---|---|
| Published in |
Archives of Dermatological Research, March 2018
|
| DOI | 10.1007/s00403-018-1828-6 |
| Pubmed ID | |
| Authors |
Alena Rajnochová Svobodová, Eva Gabrielová, Loizos Michaelides, Pavel Kosina, Alena Ryšavá, Jitka Ulrichová, Bohumil Zálešák, Jitka Vostálová |
| Abstract |
Exposure to solar radiation is a major cause of environmental human skin damage. The main constituent of solar UV light is UVA radiation (320-400 nm); however, the need for protection against UVA has been marginalized for a long time. As a result, there is still a lack of useful agents for UVA protection. In this study, the effect of silymarin (SM) and its main constituent silybin (SB) pre-treatment on UVA-stimulated damage to primary human dermal fibroblasts were carried out. The cells were pre-treated for 1 h with SB or SM and then were exposed to UVA light, using a solar simulator. The effect of SB and SM on reactive oxygen species (ROS) and glutathione (GSH) level, caspase-3 activity, single-strand breaks (SSB) formation and protein level of matrix metalloproteinase-1 (MMP-1), heme oxygenase-1 (HO-1), and heat shock protein (HSP70) was evaluated. Treatment with both SM and SB resulted in a reduction in UVA-stimulated ROS generation and SSB production, as well as in the prevention of GSH depletion, a decrease in the activation of caspase-3 and protein level of MMP-1. They also moderately increased HO-1 level and reduced HSP70 level. Our data showed that both SM and SB are non-phototoxic and have UVA-photoprotective potential and could be useful agents for UV-protective dermatological preparations. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 35 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 5 | 14% |
| Researcher | 5 | 14% |
| Student > Ph. D. Student | 4 | 11% |
| Student > Doctoral Student | 3 | 9% |
| Lecturer | 2 | 6% |
| Other | 6 | 17% |
| Unknown | 10 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 7 | 20% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 14% |
| Medicine and Dentistry | 4 | 11% |
| Chemistry | 2 | 6% |
| Agricultural and Biological Sciences | 1 | 3% |
| Other | 3 | 9% |
| Unknown | 13 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 May 2018.
All research outputs
#18,606,163
of 23,047,237 outputs
Outputs from Archives of Dermatological Research
#1,098
of 1,328 outputs
Outputs of similar age
#258,188
of 332,410 outputs
Outputs of similar age from Archives of Dermatological Research
#6
of 10 outputs
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So far Altmetric has tracked 1,328 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
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