| Title |
Protection against live rotavirus challenge in mice induced by parenteral and mucosal delivery of VP6 subunit rotavirus vaccine
|
|---|---|
| Published in |
Archives of Virology, May 2015
|
| DOI | 10.1007/s00705-015-2461-8 |
| Pubmed ID | |
| Authors |
Suvi Lappalainen, Ana Ruth Pastor, Maria Malm, Vanessa López-Guerrero, Fernando Esquivel-Guadarrama, Laura A. Palomares, Timo Vesikari, Vesna Blazevic |
| Abstract |
Live oral rotavirus (RV) vaccines are part of routine childhood immunization but are associated with adverse effects, particularly intussusception. We have developed a non-live combined RV - norovirus (NoV) vaccine candidate consisting of human RV inner-capsid rVP6 protein and NoV virus-like particles. To determine the effect of delivery route on induction of VP6-specific protective immunity, BALB/c mice were administered a vaccine containing RV rVP6 intramuscularly, intranasally or a combination of both, and challenged with murine RV. At least 65 % protection against RV shedding was observed regardless of delivery route. The levels of post-challenge serum VP6-specific IgA titers correlated with protection. |
Mendeley readers
The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| South Africa | 1 | 2% |
| Unknown | 54 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 20% |
| Researcher | 11 | 20% |
| Student > Master | 10 | 18% |
| Student > Bachelor | 3 | 5% |
| Student > Doctoral Student | 3 | 5% |
| Other | 9 | 16% |
| Unknown | 8 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 33% |
| Biochemistry, Genetics and Molecular Biology | 8 | 15% |
| Immunology and Microbiology | 6 | 11% |
| Medicine and Dentistry | 4 | 7% |
| Business, Management and Accounting | 2 | 4% |
| Other | 5 | 9% |
| Unknown | 12 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2021.
All research outputs
#5,029,422
of 23,885,338 outputs
Outputs from Archives of Virology
#405
of 4,288 outputs
Outputs of similar age
#61,148
of 268,857 outputs
Outputs of similar age from Archives of Virology
#1
of 62 outputs
Altmetric has tracked 23,885,338 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,288 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,857 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.