| Title |
What Does Imaging Reveal About the Pathology of Amyotrophic Lateral Sclerosis?
|
|---|---|
| Published in |
Current Neurology and Neuroscience Reports, May 2015
|
| DOI | 10.1007/s11910-015-0569-6 |
| Pubmed ID | |
| Authors |
Martin R. Turner, Esther Verstraete |
| Abstract |
Amyotrophic lateral sclerosis (ALS) is now recognised to be a heterogeneous neurodegenerative syndrome of the motor system and its frontotemporal cortical connections. The development and application of structural and functional imaging over the last three decades, in particular magnetic resonance imaging (MRI), has allowed traditional post mortem histopathological and emerging molecular findings in ALS to be placed in a clinical context. Cerebral grey and white matter structural MRI changes are increasingly being understood in terms of brain connectivity, providing insights into the advancing degenerative process and producing candidate biomarkers. Such markers may refine the prognostic stratification of patients and the diagnostic pathway, as well as providing an objective assessment of changes in disease activity in response to future therapeutic agents. Studies are being extended to the spinal cord, and the application of neuroimaging to unaffected carriers of highly penetrant genetic mutations linked to the development of ALS offers a unique window to the pre-symptomatic landscape. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | <1% |
| Australia | 1 | <1% |
| Brazil | 1 | <1% |
| Belgium | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 97 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 20% |
| Researcher | 13 | 13% |
| Student > Bachelor | 13 | 13% |
| Student > Doctoral Student | 9 | 9% |
| Other | 9 | 9% |
| Other | 24 | 24% |
| Unknown | 14 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 39 | 38% |
| Neuroscience | 23 | 23% |
| Psychology | 6 | 6% |
| Agricultural and Biological Sciences | 5 | 5% |
| Biochemistry, Genetics and Molecular Biology | 5 | 5% |
| Other | 5 | 5% |
| Unknown | 19 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 October 2017.
All research outputs
#3,119,437
of 22,807,037 outputs
Outputs from Current Neurology and Neuroscience Reports
#178
of 914 outputs
Outputs of similar age
#42,365
of 266,750 outputs
Outputs of similar age from Current Neurology and Neuroscience Reports
#7
of 22 outputs
Altmetric has tracked 22,807,037 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 914 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,750 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.