| Title |
Effect-based assessment of persistent organic pollutant and pesticide dumpsite using mammalian CALUX reporter cell lines
|
|---|---|
| Published in |
Environmental Science and Pollution Research, May 2015
|
| DOI | 10.1007/s11356-015-4739-5 |
| Pubmed ID | |
| Authors |
B. Pieterse, I. J. C. Rijk, E. Simon, B. M. A. van Vugt-Lussenburg, B. F. H. Fokke, M. van der Wijk, H. Besselink, R. Weber, B. van der Burg |
| Abstract |
A combined chemical and biological analysis of samples from a major obsolete pesticide and persistent organic pollutant (POP) dumpsite in Northern Tajikistan was carried out. The chemical analytical screening focused on a range of prioritized compounds and compounds known to be present locally. Since chemical analytics does not allow measurements of hazards in complex mixtures, we tested the use of a novel effect-based approach using a panel of quantitative high-throughput CALUX reporter assays measuring distinct biological effects relevant in hazard assessment. Assays were included for assessing effects related to estrogen, androgen, and progestin signaling, aryl hydrocarbon receptor-mediated signaling, AP1 signaling, genotoxicity, oxidative stress, chemical hypoxia, and ER stress. With this panel of assays, we first quantified the biological activities of the individual chemicals measured in chemical analytics. Next, we calculated the expected sum activity by these chemicals in the samples of the pesticide dump site and compared the results with the measured CALUX bioactivity of the total extracts of these samples. The results showed that particularly endocrine disruption-related effects were common among the samples. This was consistent with the toxicological profiles of the individual chemicals that dominated these samples. However, large discrepancies between chemical and biological analysis were found in a sample from a burn place present in this site, with biological activities that could not be explained by chemical analysis. This is likely to be caused by toxic combustion products or by spills of compounds that were not targeted in the chemical analysis. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 42 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 17% |
| Student > Ph. D. Student | 7 | 17% |
| Student > Master | 4 | 10% |
| Other | 3 | 7% |
| Unspecified | 2 | 5% |
| Other | 7 | 17% |
| Unknown | 12 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Environmental Science | 11 | 26% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 10% |
| Medicine and Dentistry | 3 | 7% |
| Agricultural and Biological Sciences | 3 | 7% |
| Unspecified | 2 | 5% |
| Other | 6 | 14% |
| Unknown | 13 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 May 2015.
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#21,420,714
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#7,000
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Outputs of similar age from Environmental Science and Pollution Research
#124
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