Chapter title |
NK Cells and Cancer Immunoediting.
|
---|---|
Chapter number | 446 |
Book title |
Natural Killer Cells
|
Published in |
Current topics in microbiology and immunology, May 2015
|
DOI | 10.1007/82_2015_446 |
Pubmed ID | |
Book ISBNs |
978-3-31-923915-6, 978-3-31-923916-3
|
Authors |
Guillerey, Camille, Smyth, Mark J, Camille Guillerey, Mark J. Smyth, Smyth, Mark J. |
Abstract |
Natural killer (NK) cells are innate lymphoid cells (ILC) known for their ability to recognize and rapidly eliminate infected or transformed cells. Consequently, NK cells are fundamental for host protection against virus infections and malignancies. Even though the critical role of NK cells in cancer immunosurveillance was suspected years ago, the underlying mechanisms took time to be unraveled. Today, it is clear that anti-tumor functions of NK cells are tightly regulated and expand far beyond the simple killing of malignant cells. In spite of tremendous steps made in understanding the NK cell biology, further work is warranted to fully exploit the anticancer potential of these cells. Indeed, tumor-mediated immune suppression hampers NK cell activity, thus complicating their stimulation for therapeutic purposes. Herein, we review the current knowledge of NK cell functions in anti-tumor immunity . We discuss NK cell activity in the cancer immunoediting process with particular emphasis on the elimination and escape phases. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 72 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 22 | 31% |
Student > Master | 11 | 15% |
Student > Bachelor | 7 | 10% |
Student > Doctoral Student | 4 | 6% |
Researcher | 4 | 6% |
Other | 5 | 7% |
Unknown | 19 | 26% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 19 | 26% |
Biochemistry, Genetics and Molecular Biology | 15 | 21% |
Agricultural and Biological Sciences | 7 | 10% |
Medicine and Dentistry | 6 | 8% |
Engineering | 2 | 3% |
Other | 5 | 7% |
Unknown | 18 | 25% |