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Mendeley readers
Attention Score in Context
| Title |
Common variants on chromosome 6p22.1 are associated with schizophrenia
|
|---|---|
| Published in |
Nature, July 2009
|
| DOI | 10.1038/nature08192 |
| Pubmed ID | |
| Authors |
Jianxin Shi, Douglas F. Levinson, Jubao Duan, Alan R. Sanders, Yonglan Zheng, Itsik Pe’er, Frank Dudbridge, Peter A. Holmans, Alice S. Whittemore, Bryan J. Mowry, Ann Olincy, Farooq Amin, C. Robert Cloninger, Jeremy M. Silverman, Nancy G. Buccola, William F. Byerley, Donald W. Black, Raymond R. Crowe, Jorge R. Oksenberg, Daniel B. Mirel, Kenneth S. Kendler, Robert Freedman, Pablo V. Gejman |
| Abstract |
Schizophrenia, a devastating psychiatric disorder, has a prevalence of 0.5-1%, with high heritability (80-85%) and complex transmission. Recent studies implicate rare, large, high-penetrance copy number variants in some cases, but the genes or biological mechanisms that underlie susceptibility are not known. Here we show that schizophrenia is significantly associated with single nucleotide polymorphisms (SNPs) in the extended major histocompatibility complex region on chromosome 6. We carried out a genome-wide association study of common SNPs in the Molecular Genetics of Schizophrenia (MGS) case-control sample, and then a meta-analysis of data from the MGS, International Schizophrenia Consortium and SGENE data sets. No MGS finding achieved genome-wide statistical significance. In the meta-analysis of European-ancestry subjects (8,008 cases, 19,077 controls), significant association with schizophrenia was observed in a region of linkage disequilibrium on chromosome 6p22.1 (P = 9.54 x 10(-9)). This region includes a histone gene cluster and several immunity-related genes--possibly implicating aetiological mechanisms involving chromatin modification, transcriptional regulation, autoimmunity and/or infection. These results demonstrate that common schizophrenia susceptibility alleles can be detected. The characterization of these signals will suggest important directions for research on susceptibility mechanisms. |
Mendeley readers
The data shown below were compiled from readership statistics for 659 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 13 | 2% |
| United States | 12 | 2% |
| Japan | 4 | <1% |
| Germany | 3 | <1% |
| Netherlands | 2 | <1% |
| Switzerland | 1 | <1% |
| Cuba | 1 | <1% |
| Hong Kong | 1 | <1% |
| Sweden | 1 | <1% |
| Other | 6 | <1% |
| Unknown | 615 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 125 | 19% |
| Researcher | 121 | 18% |
| Student > Master | 70 | 11% |
| Student > Bachelor | 64 | 10% |
| Professor > Associate Professor | 52 | 8% |
| Other | 135 | 20% |
| Unknown | 92 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 196 | 30% |
| Medicine and Dentistry | 109 | 17% |
| Biochemistry, Genetics and Molecular Biology | 74 | 11% |
| Neuroscience | 69 | 10% |
| Psychology | 46 | 7% |
| Other | 50 | 8% |
| Unknown | 115 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 49. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 March 2020.
All research outputs
#867,669
of 25,837,817 outputs
Outputs from Nature
#29,942
of 98,779 outputs
Outputs of similar age
#2,233
of 126,553 outputs
Outputs of similar age from Nature
#51
of 512 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 98,779 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 102.5. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 126,553 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 512 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.