| Title |
IDH mutation status and role of WHO grade and mitotic index in overall survival in grade II–III diffuse gliomas
|
|---|---|
| Published in |
Acta Neuropathologica, February 2015
|
| DOI | 10.1007/s00401-015-1398-z |
| Pubmed ID | |
| Authors |
Adriana Olar, Khalida M. Wani, Kristin D. Alfaro-Munoz, Lindsey E. Heathcock, Hinke F. van Thuijl, Mark R. Gilbert, Terri S. Armstrong, Erik P. Sulman, Daniel P. Cahill, Elizabeth Vera-Bolanos, Ying Yuan, Jaap C. Reijneveld, Bauke Ylstra, Pieter Wesseling, Kenneth D. Aldape |
| Abstract |
Diffuse gliomas are up till now graded based upon morphology. Recent findings indicate that isocitrate dehydrogenase (IDH) mutation status defines biologically distinct groups of tumors. The role of tumor grade and mitotic index in patient outcome has not been evaluated following stratification by IDH mutation status. To address this, we interrogated 558 WHO grade II-III diffuse gliomas for IDH1/2 mutations and investigated the prognostic impact of WHO grade within IDH-mutant and IDH-wild type tumor subsets independently. The prognostic impact of grade was modest in IDH-mutant [hazard ratio (HR) = 1.21, 95 % confidence interval (CI) = 0.91-1.61] compared to IDH-wild type tumors (HR = 1.74, 95 % CI = 0.95-3.16). Using a dichotomized mitotic index cut-off of 4/1000 tumor cells, we found that while mitotic index was significantly associated with outcome in IDH-wild type tumors (log-rank p < 0.0001, HR = 4.41, 95 % CI = 2.55-7.63), it was not associated with outcome in IDH-mutant tumors (log-rank p = 0.5157, HR = 1.10, 95 % CI = 0.80-1.51), and could demonstrate a statistical interaction (p < 0.0001) between IDH mutation and mitotic index (i.e., suggesting that the effect of mitotic index on patient outcome is dependent on IDH mutation status). Patient age, an established prognostic factor in diffuse glioma, was significantly associated with outcome only in the IDH-wild type subset, and consistent with prior data, 1p/19q co-deletion conferred improved outcome in the IDH-mutant cohort. These findings suggest that stratification of grade II-III gliomas into subsets defined by the presence or absence of IDH mutation leads to subgroups with distinct prognostic characteristics. Further evaluation of grading criteria and prognostic markers is warranted within IDH-mutant versus IDH-wild type diffuse grade II-III gliomas as independent entities. |
Mendeley readers
The data shown below were compiled from readership statistics for 185 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| Netherlands | 1 | <1% |
| Nigeria | 1 | <1% |
| Unknown | 182 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 11% |
| Researcher | 20 | 11% |
| Student > Master | 18 | 10% |
| Other | 17 | 9% |
| Student > Doctoral Student | 16 | 9% |
| Other | 50 | 27% |
| Unknown | 44 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 78 | 42% |
| Biochemistry, Genetics and Molecular Biology | 15 | 8% |
| Neuroscience | 13 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 2% |
| Agricultural and Biological Sciences | 3 | 2% |
| Other | 19 | 10% |
| Unknown | 53 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 May 2015.
All research outputs
#15,334,706
of 22,808,725 outputs
Outputs from Acta Neuropathologica
#2,099
of 2,369 outputs
Outputs of similar age
#150,976
of 255,024 outputs
Outputs of similar age from Acta Neuropathologica
#20
of 27 outputs
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