You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States
|
|---|---|
| Published in |
Diabetes, August 2006
|
| DOI | 10.2337/db06-0006 |
| Pubmed ID | |
| Authors |
Yun S. Lee, Woo S. Kim, Kang H. Kim, Myung J. Yoon, Hye J. Cho, Yun Shen, Ji-Ming Ye, Chul H. Lee, Won K. Oh, Chul T. Kim, Cordula Hohnen-Behrens, Alison Gosby, Edward W. Kraegen, David E. James, Jae B. Kim |
| Abstract |
Berberine has been shown to have antidiabetic properties, although its mode of action is not known. Here, we have investigated the metabolic effects of berberine in two animal models of insulin resistance and in insulin-responsive cell lines. Berberine reduced body weight and caused a significant improvement in glucose tolerance without altering food intake in db/db mice. Similarly, berberine reduced body weight and plasma triglycerides and improved insulin action in high-fat-fed Wistar rats. Berberine downregulated the expression of genes involved in lipogenesis and upregulated those involved in energy expenditure in adipose tissue and muscle. Berberine treatment resulted in increased AMP-activated protein kinase (AMPK) activity in 3T3-L1 adipocytes and L6 myotubes, increased GLUT4 translocation in L6 cells in a phosphatidylinositol 3' kinase-independent manner, and reduced lipid accumulation in 3T3-L1 adipocytes. These findings suggest that berberine displays beneficial effects in the treatment of diabetes and obesity at least in part via stimulation of AMPK activity. |
X Demographics
The data shown below were collected from the profiles of 90 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 29 | 32% |
| United Kingdom | 7 | 8% |
| Canada | 5 | 6% |
| France | 2 | 2% |
| India | 2 | 2% |
| Poland | 1 | 1% |
| South Africa | 1 | 1% |
| Hungary | 1 | 1% |
| Mexico | 1 | 1% |
| Other | 3 | 3% |
| Unknown | 38 | 42% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 70 | 78% |
| Practitioners (doctors, other healthcare professionals) | 14 | 16% |
| Science communicators (journalists, bloggers, editors) | 2 | 2% |
| Scientists | 2 | 2% |
| Unknown | 2 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 399 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 2% |
| Switzerland | 2 | <1% |
| Australia | 1 | <1% |
| United Kingdom | 1 | <1% |
| Italy | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| China | 1 | <1% |
| Japan | 1 | <1% |
| Russia | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 383 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 65 | 16% |
| Researcher | 47 | 12% |
| Student > Master | 44 | 11% |
| Student > Bachelor | 38 | 10% |
| Professor | 22 | 6% |
| Other | 105 | 26% |
| Unknown | 78 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 99 | 25% |
| Biochemistry, Genetics and Molecular Biology | 64 | 16% |
| Medicine and Dentistry | 52 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 31 | 8% |
| Chemistry | 11 | 3% |
| Other | 38 | 10% |
| Unknown | 104 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 210. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 February 2024.
All research outputs
#189,044
of 25,718,113 outputs
Outputs from Diabetes
#49
of 9,747 outputs
Outputs of similar age
#239
of 90,918 outputs
Outputs of similar age from Diabetes
#1
of 52 outputs
Altmetric has tracked 25,718,113 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,747 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.6. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 90,918 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.