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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets
|
|---|---|
| Published in |
Cell, January 2005
|
| DOI | 10.1016/j.cell.2004.12.035 |
| Pubmed ID | |
| Authors |
Benjamin P. Lewis, Christopher B. Burge, David P. Bartel |
| Abstract |
We predict regulatory targets of vertebrate microRNAs (miRNAs) by identifying mRNAs with conserved complementarity to the seed (nucleotides 2-7) of the miRNA. An overrepresentation of conserved adenosines flanking the seed complementary sites in mRNAs indicates that primary sequence determinants can supplement base pairing to specify miRNA target recognition. In a four-genome analysis of 3' UTRs, approximately 13,000 regulatory relationships were detected above the estimate of false-positive predictions, thereby implicating as miRNA targets more than 5300 human genes, which represented 30% of our gene set. Targeting was also detected in open reading frames. In sum, well over one third of human genes appear to be conserved miRNA targets. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 3,740 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 45 | 1% |
| United Kingdom | 27 | <1% |
| Germany | 20 | <1% |
| Brazil | 13 | <1% |
| Spain | 12 | <1% |
| Italy | 10 | <1% |
| Japan | 8 | <1% |
| Denmark | 6 | <1% |
| China | 6 | <1% |
| Other | 71 | 2% |
| Unknown | 3522 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 954 | 26% |
| Researcher | 655 | 18% |
| Student > Master | 488 | 13% |
| Student > Bachelor | 392 | 10% |
| Student > Doctoral Student | 217 | 6% |
| Other | 522 | 14% |
| Unknown | 512 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 1403 | 38% |
| Biochemistry, Genetics and Molecular Biology | 862 | 23% |
| Medicine and Dentistry | 339 | 9% |
| Computer Science | 103 | 3% |
| Neuroscience | 72 | 2% |
| Other | 346 | 9% |
| Unknown | 615 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 31. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 March 2024.
All research outputs
#1,293,750
of 25,837,817 outputs
Outputs from Cell
#4,442
of 17,278 outputs
Outputs of similar age
#2,597
of 153,898 outputs
Outputs of similar age from Cell
#8
of 68 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,278 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 59.7. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 153,898 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.