| Title |
Glutamate transporter EAAT2: regulation, function, and potential as a therapeutic target for neurological and psychiatric disease
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, June 2015
|
| DOI | 10.1007/s00018-015-1937-8 |
| Pubmed ID | |
| Authors |
Kou Takahashi, Joshua B. Foster, Chien-Liang Glenn Lin |
| Abstract |
Glutamate is the predominant excitatory neurotransmitter in the central nervous system. Excitatory amino acid transporter 2 (EAAT2) is primarily responsible for clearance of extracellular glutamate to prevent neuronal excitotoxicity and hyperexcitability. EAAT2 plays a critical role in regulation of synaptic activity and plasticity. In addition, EAAT2 has been implicated in the pathogenesis of many central nervous system disorders. In this review, we summarize current understanding of EAAT2, including structure, pharmacology, physiology, and functions, as well as disease relevancy, such as in stroke, Parkinson's disease, epilepsy, amyotrophic lateral sclerosis, Alzheimer's disease, major depressive disorder, and addiction. A large number of studies have demonstrated that up-regulation of EAAT2 protein provides significant beneficial effects in many disease models suggesting EAAT2 activation is a promising therapeutic approach. Several EAAT2 activators have been identified. Further understanding of EAAT2 regulatory mechanisms could improve development of drug-like compounds that spatiotemporally regulate EAAT2. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 171 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Unknown | 170 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 35 | 20% |
| Researcher | 34 | 20% |
| Student > Master | 24 | 14% |
| Student > Bachelor | 17 | 10% |
| Other | 9 | 5% |
| Other | 19 | 11% |
| Unknown | 33 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 45 | 26% |
| Agricultural and Biological Sciences | 25 | 15% |
| Medicine and Dentistry | 19 | 11% |
| Biochemistry, Genetics and Molecular Biology | 18 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
| Other | 16 | 9% |
| Unknown | 42 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 June 2015.
All research outputs
#21,141,111
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#3,769
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Outputs of similar age
#225,653
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Outputs of similar age from Cellular and Molecular Life Sciences
#49
of 56 outputs
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