| Title |
Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand
|
|---|---|
| Published in |
Diabetologia, May 2018
|
| DOI | 10.1007/s00125-018-4623-1 |
| Pubmed ID | |
| Authors |
Mohanraj Krishnan, Tanya J. Major, Ruth K. Topless, Ofa Dewes, Lennex Yu, John M. D. Thompson, Lesley McCowan, Janak de Zoysa, Lisa K. Stamp, Nicola Dalbeth, Jennie Harré Hindmarsh, Nuku Rapana, Ranjan Deka, Winston W. H. Eng, Daniel E. Weeks, Ryan L. Minster, Stephen T. McGarvey, Satupa’itea Viali, Take Naseri, Muagututi’a Sefuiva Reupena, Phillip Wilcox, David Grattan, Peter R. Shepherd, Andrew N. Shelling, Rinki Murphy, Tony R. Merriman |
| Abstract |
The A (minor) allele of CREBRF rs373863828 has been associated with increased BMI and reduced risk of type 2 diabetes in the Samoan populations of Samoa and American Samoa. Our aim was to test rs373863828 for associations with BMI and the odds of type 2 diabetes, gout and chronic kidney disease (CKD) in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand. Linear and logistic regression models were used to analyse the association of the A allele of CREBRF rs373863828 with BMI, log-transformed BMI, waist circumference, type 2 diabetes, gout and CKD in 2286 adults. The primary analyses were adjusted for age, sex, the first four genome-wide principal components and (where appropriate) BMI, waist circumference and type 2 diabetes. The primary analysis was conducted in ancestrally defined groups and association effects were combined using meta-analysis. For the A allele of rs373863828, the effect size was 0.038 (95% CI 0.022, 0.055, p = 4.8 × 10-6) for log-transformed BMI, with OR 0.59 (95% CI 0.47, 0.73, p = 1.9 × 10-6) for type 2 diabetes. There was no evidence for an association of genotype with variance in BMI (p = 0.13), and nor was there evidence for associations with serum urate (β = 0.012 mmol/l, pcorrected = 0.10), gout (OR 1.00, p = 0.98) or CKD (OR 0.91, p = 0.59). Our results in New Zealand Polynesian adults replicate, with very similar effect sizes, the association of the A allele of rs373863828 with higher BMI but lower odds of type 2 diabetes among Samoan adults living in Samoa and American Samoa. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| New Zealand | 3 | 43% |
| United States | 1 | 14% |
| Chile | 1 | 14% |
| Unknown | 2 | 29% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 57% |
| Scientists | 2 | 29% |
| Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 90 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 13% |
| Researcher | 12 | 13% |
| Student > Master | 9 | 10% |
| Student > Postgraduate | 8 | 9% |
| Student > Bachelor | 6 | 7% |
| Other | 18 | 20% |
| Unknown | 25 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 23 | 26% |
| Medicine and Dentistry | 20 | 22% |
| Nursing and Health Professions | 5 | 6% |
| Social Sciences | 3 | 3% |
| Agricultural and Biological Sciences | 3 | 3% |
| Other | 8 | 9% |
| Unknown | 28 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 June 2021.
All research outputs
#6,503,285
of 24,024,220 outputs
Outputs from Diabetologia
#2,639
of 5,206 outputs
Outputs of similar age
#108,179
of 329,996 outputs
Outputs of similar age from Diabetologia
#42
of 56 outputs
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