| Title |
The potential European genetic predisposition for non‐contact anterior cruciate ligament injury
|
|---|---|
| Published in |
Knee Surgery, Sports Traumatology, Arthroscopy, May 2018
|
| DOI | 10.1007/s00167-018-4974-7 |
| Pubmed ID | |
| Authors |
Diego Costa Astur, Edilson Andrade, Gustavo Gonçalves Arliani, Pedro Debieux, Leonor Casilla Loyola, Sidney Emanuel Batista dos Santos, Rommel Mario Rodriguez Burbano, Mariana Ferreira Leal, Moises Cohen |
| Abstract |
Previous research has provided evidence of a hereditary predisposition for anterior cruciate ligament (ACL) injury. The purpose of this study was to evaluate the association between ancestral population genetics and risk of non-contact ACL injuries. Blood samples were collected from 177 individuals with a history of non-contact ACL injury and 556 non-injured control individuals for analysis of the genetic material through the use of a panel of 48 INDELs ancestry genetic markers from three ancestral origins. Among patients with non-contact ACL injury, 82% were male and 18% were female. In the control group, 78% were male, and 22% were female. The mean age of the non-contact ACL injury group was 31.7 years (± 10.2), and the control group was 33.8 years (± 13.2). The individual genetic contribution from INDELs of each ancestral origin varied considerably: ranging between 1.5-94.8% contribution for INDELs of African origin (mean of 21.4% of INDELs); between 2 and 96.1% contribution for INDELs of European origin (mean of 66.7% of INDELs); and between 1.3-96.4% contribution for INDELs of Amerindian origin (mean of 11.7% of INDELs). When comparing paired subjects from the non-contact ACL and control groups, the genetic analysis showed that the European ancestry score was higher in the non-contact ACL group than control group (0.70 ± 0.21 vs 0.63 ± 0.22 respectively, p < 0.001), whereas African ancestry scores (ACL group 0.18 ± 0.18 vs control group 0.24 ± 0.21, p < 0.001) and Amerindian ancestry scores (ACL group 0.11 ± 0.09 vs control group 0.12 ± 0.10, n.s.) were lower among the non-contact ACL group than in controls. European INDELs markers were found to represent a potential genetic predisposition for non-contact ACL injuries when compared to African and Amerindian INDELs. This study has the potential to correlate a measurable and distinct genetic marker with risk of a non-contact ACL injury. Thus, it increases knowledge base and volume of molecular and genetical factors associated with this pathology. Furthermore, this study provides guidance and evidence for the development of genetic risk-screening panels for non-contact ACL injury. Level III Diagnostic Study. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 50% |
| United Kingdom | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 38 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 8 | 21% |
| Student > Ph. D. Student | 5 | 13% |
| Student > Doctoral Student | 3 | 8% |
| Other | 2 | 5% |
| Researcher | 2 | 5% |
| Other | 2 | 5% |
| Unknown | 16 | 42% |
| Readers by discipline | Count | As % |
|---|---|---|
| Sports and Recreations | 6 | 16% |
| Nursing and Health Professions | 5 | 13% |
| Biochemistry, Genetics and Molecular Biology | 3 | 8% |
| Medicine and Dentistry | 3 | 8% |
| Psychology | 1 | 3% |
| Other | 3 | 8% |
| Unknown | 17 | 45% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 September 2020.
All research outputs
#14,390,935
of 23,047,237 outputs
Outputs from Knee Surgery, Sports Traumatology, Arthroscopy
#1,608
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Outputs of similar age
#185,552
of 326,669 outputs
Outputs of similar age from Knee Surgery, Sports Traumatology, Arthroscopy
#19
of 37 outputs
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