| Title |
Frontal lobe functioning during a simple response conflict task in first-episode psychosis and its relationship to treatment response
|
|---|---|
| Published in |
Brain Imaging and Behavior, May 2018
|
| DOI | 10.1007/s11682-018-9876-2 |
| Pubmed ID | |
| Authors |
Keith M. Shafritz, Toshikazu Ikuta, Allison Greene, Delbert G. Robinson, Juan Gallego, Todd Lencz, Pamela DeRosse, Peter B. Kingsley, Philip R. Szeszko |
| Abstract |
Prior functional magnetic resonance imaging (fMRI) studies have investigated the neural mechanisms underlying cognitive control in patients with psychosis with findings of both hypo- and hyperfrontality. One factor that may contribute to inconsistent findings is the use of complex and polyfactorial tasks to investigate frontal lobe functioning. In the current study we employed a simple response conflict task during fMRI to examine differences in brain activation between patients experiencing their first-episode of psychosis (n = 33) and age- and sex-matched healthy volunteers (n = 33). We further investigated whether baseline brain activation among patients predicted changes in symptom severity and treatment response following 12 weeks of controlled antipsychotic treatment. During the task subjects were instructed to press a response button on the same side or opposite side of a circle that appeared on either side of a central fixation point. Imaging data revealed that for the contrast of opposite-side vs. same-side, patients showed significantly greater activation compared with healthy volunteers in the anterior cingulate cortex and intraparietal sulcus. Among patients, greater baseline anterior cingulate cortex, temporal-parietal junction, and superior temporal cortex activation predicted greater symptom reduction and therapeutic response following treatment. All findings remained significant after covarying for task performance. Intact performance on this relatively parsimonious task was associated with frontal hyperactivity suggesting the need for patients to utilize greater neural resources to achieve task performance comparable to healthy individuals. Moreover, frontal hyperactivity observed using a simple fMRI task may provide a biomarker for predicting treatment response in first-episode psychosis. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 50% |
| United States | 1 | 25% |
| Italy | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 78 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 13% |
| Student > Bachelor | 9 | 12% |
| Researcher | 8 | 10% |
| Student > Doctoral Student | 7 | 9% |
| Student > Ph. D. Student | 6 | 8% |
| Other | 13 | 17% |
| Unknown | 25 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 14 | 18% |
| Medicine and Dentistry | 10 | 13% |
| Nursing and Health Professions | 9 | 12% |
| Neuroscience | 8 | 10% |
| Biochemistry, Genetics and Molecular Biology | 2 | 3% |
| Other | 5 | 6% |
| Unknown | 30 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 August 2019.
All research outputs
#14,107,269
of 23,047,237 outputs
Outputs from Brain Imaging and Behavior
#537
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Outputs of similar age
#179,049
of 327,425 outputs
Outputs of similar age from Brain Imaging and Behavior
#27
of 48 outputs
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