| Title |
RETRACTED ARTICLE: Development and In Vitro-In Vivo Characterization of Chronomodulated Pulsatile Delivery Formulation of Terbutaline Sulphate by Box-Behnken Statistical Design
|
|---|---|
| Published in |
AAPS PharmSciTech, June 2017
|
| DOI | 10.1208/s12249-017-0838-6 |
| Pubmed ID | |
| Authors |
Prabhjot Singh Bajwa, Anurag Bhargava, Jaya Sharma, Shailesh Sharma, Abhimanyu Rai Sharma, Binu Sharma |
| Abstract |
In the present study, we have designed a press-coated pulsatile delivery tablet (PDT) of Terbutaline sulphate (TS) intended for prevention of early-morning asthma attacks. The formulation is capable of giving burst release of drug after 6 h of lag time. In this study, a press-coating technique was employed to coat a fast-release core tablet containing TS with a polymeric release retarding coat comprising of ethyl cellulose, HPMC K15M and Carbopol 971P. Fast-release core tablets were formulated using sodium starch glycolate with croscarmellose sodium (disintegrants). Optimization of PDT was done by response surface methodology employing the Box-Behnken design. The formulations underwent physical evaluation and drug release study. A lag time of 6 h was obtained by the optimized PDT formulation (OP1). The accelerated stability studies showed no significant changes in physicochemical properties and release behaviour before and after storage. Further in vivo pharmacokinetic studies were performed on rabbits to determine pharmacokinetic parameters. The formulation OP1 showed C max and T max values of 162.92 ± 9.85 ng/mL and 10 h, respectively. A large value of MRT for the formulation OP1 (12.34 ± 0.778 h) signifies that formulation OP1 was able to delay the release. The study concludes that the chronotherapeutic PDT of TS can be successfully formulated and used to provide a pulsatile release for the chronotherapy of nocturnal asthma. |
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 2 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Professor > Associate Professor | 1 | 50% |
| Other | 1 | 50% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 50% |
| Unknown | 1 | 50% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 December 2018.
All research outputs
#2,687,492
of 23,047,237 outputs
Outputs from AAPS PharmSciTech
#54
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Outputs of similar age
#51,738
of 314,625 outputs
Outputs of similar age from AAPS PharmSciTech
#1
of 16 outputs
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