Title |
Haematological and fibrinolytic status of Nigerian women with post-partum haemorrhage
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Published in |
BMC Pregnancy and Childbirth, May 2018
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DOI | 10.1186/s12884-018-1794-1 |
Pubmed ID | |
Authors |
Ian Roberts, Haleema Shakur, Bukola Fawole, Modupe Kuti, Oladapo Olayemi, Adenike Bello, Olayinka Ogunbode, Taiwo Kotila, Chris O. Aimakhu, Tolulase Olutogun, Beverley J. Hunt, Sumaya Huque |
Abstract |
Early treatment with tranexamic acid reduces deaths due to bleeding after post-partum haemorrhage. We report the prevalence of haematological, coagulation and fibrinolytic abnormalities in Nigerian women with postpartum haemorrhage. We performed a secondary analysis of the WOMAN trial to assess laboratory data and rotational thromboelastometry (ROTEM) parameters in 167 women with postpartum haemorrhage treated at University College Hospital, Ibadan, Nigeria. We defined hyper-fibrinolysis as EXTEM maximum lysis (ML) > 15% on ROTEM. We defined coagulopathy as EXTEM clot amplitude at 5 min (A5) < 40 mm or prothrombin ratio > 1.5. Among the study cohort, 53 (40%) women had severe anaemia (haemoglobin< 70 g/L) and 17 (13%) women had severe thrombocytopenia (platelet count < 50 × 109/L). Thirty-five women (23%) had ROTEM evidence of hyper-fibrinolysis. Based on prothrombin ratio criteria, 16 (12%) had coagulopathy. Based on EXTEM A5 criteria, 49 (34%) had coagulopathy. Our findings suggest that, based on a convenience sample of women from a large teaching hospital in Nigeria, hyper-fibrinolysis may commonly occur in postpartum haemorrhage. Further mechanistic studies are needed to examine hyper-fibrinolysis associated with postpartum haemorrhage. Findings from such studies may optimize treatment approaches for postpartum haemorrhage. The Woman trial was registered: NCT00872469; ISRCTN76912190 (Registration date: 22/03/2012). |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 6 | 21% |
United States | 4 | 14% |
Australia | 3 | 11% |
France | 2 | 7% |
Colombia | 1 | 4% |
Unknown | 12 | 43% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 15 | 54% |
Practitioners (doctors, other healthcare professionals) | 9 | 32% |
Scientists | 3 | 11% |
Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 81 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 14% |
Student > Postgraduate | 11 | 14% |
Student > Master | 10 | 12% |
Student > Bachelor | 5 | 6% |
Other | 5 | 6% |
Other | 16 | 20% |
Unknown | 23 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 33 | 41% |
Nursing and Health Professions | 6 | 7% |
Social Sciences | 3 | 4% |
Chemistry | 3 | 4% |
Biochemistry, Genetics and Molecular Biology | 2 | 2% |
Other | 3 | 4% |
Unknown | 31 | 38% |