Title |
Effects of reactive oxygen species and interplay of antioxidants during physical exercise in skeletal muscles
|
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Published in |
Journal of Physiology and Biochemistry, May 2018
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DOI | 10.1007/s13105-018-0633-1 |
Pubmed ID | |
Authors |
Anand Thirupathi, Ricardo A. Pinho |
Abstract |
A large number of researches have led to a substantial growth of knowledge about exercise and oxidative stress. Initial investigations reported that physical exercise generates free radical-mediated damages to cells; however, in recent years, studies have shown that regular exercise can upregulate endogenous antioxidants and reduce oxidative damage. Yet, strenuous exercise perturbs the antioxidant system by increasing the reactive oxygen species (ROS) content. These alterations in the cellular environment seem to occur in an exercise type-dependent manner. The source of ROS generation during exercise is debatable, but now it is well established that both contracting and relaxing skeletal muscles generate reactive oxygen species and reactive nitrogen species. In particular, exercises of higher intensity and longer duration can cause oxidative damage to lipids, proteins, and nucleotides in myocytes. In this review, we summarize the ROS effects and interplay of antioxidants in skeletal muscle during physical exercise. Additionally, we discuss how ROS-mediated signaling influences physical exercise in antioxidant system. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 20% |
United Kingdom | 2 | 20% |
Chile | 1 | 10% |
India | 1 | 10% |
Unknown | 4 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 6 | 60% |
Members of the public | 3 | 30% |
Practitioners (doctors, other healthcare professionals) | 1 | 10% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 118 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 19 | 16% |
Researcher | 15 | 13% |
Student > Bachelor | 15 | 13% |
Student > Ph. D. Student | 13 | 11% |
Student > Doctoral Student | 6 | 5% |
Other | 22 | 19% |
Unknown | 28 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Sports and Recreations | 32 | 27% |
Medicine and Dentistry | 16 | 14% |
Biochemistry, Genetics and Molecular Biology | 16 | 14% |
Nursing and Health Professions | 10 | 8% |
Psychology | 3 | 3% |
Other | 6 | 5% |
Unknown | 35 | 30% |