| Title |
Genetics of caffeine consumption and responses to caffeine
|
|---|---|
| Published in |
Psychopharmacology, June 2010
|
| DOI | 10.1007/s00213-010-1900-1 |
| Pubmed ID | |
| Authors |
Amy Yang, Abraham A. Palmer, Harriet de Wit |
| Abstract |
Caffeine is widely consumed in foods and beverages and is also used for a variety of medical purposes. Despite its widespread use, relatively little is understood regarding how genetics affects consumption, acute response, or the long-term effects of caffeine. This paper reviews the literature on the genetics of caffeine from the following: (1) twin studies comparing heritability of consumption and of caffeine-related traits, including withdrawal symptoms, caffeine-induced insomnia, and anxiety, (2) association studies linking genetic polymorphisms of metabolic enzymes and target receptors to variations in caffeine response, and (3) case-control and prospective studies examining relationship between polymorphisms associated with variations in caffeine response to risks of Parkinson's and cardiovascular diseases in habitual caffeine consumers. Twin studies find the heritability of caffeine-related traits to range between 0.36 and 0.58. Analysis of polysubstance use shows that predisposition to caffeine use is highly specific to caffeine itself and shares little common disposition to use of other substances. Genome association studies link variations in adenosine and dopamine receptors to caffeine-induced anxiety and sleep disturbances. Polymorphism in the metabolic enzyme cytochrome P-450 is associated with risk of myocardial infarction in caffeine users. Modeling based on twin studies reveals that genetics plays a role in individual variability in caffeine consumption and in the direct effects of caffeine. Both pharmacodynamic and pharmacokinetic polymorphisms have been linked to variation in response to caffeine. These studies may help guide future research in the role of genetics in modulating the acute and chronic effects of caffeine. |
X Demographics
The data shown below were collected from the profiles of 41 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 10% |
| United Kingdom | 4 | 10% |
| Japan | 4 | 10% |
| Finland | 1 | 2% |
| Italy | 1 | 2% |
| India | 1 | 2% |
| Brazil | 1 | 2% |
| Spain | 1 | 2% |
| Unknown | 24 | 59% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 29 | 71% |
| Practitioners (doctors, other healthcare professionals) | 7 | 17% |
| Scientists | 5 | 12% |
Mendeley readers
The data shown below were compiled from readership statistics for 538 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | <1% |
| Chile | 2 | <1% |
| Spain | 2 | <1% |
| Italy | 1 | <1% |
| Malaysia | 1 | <1% |
| Russia | 1 | <1% |
| Unknown | 528 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 164 | 30% |
| Student > Master | 80 | 15% |
| Student > Ph. D. Student | 51 | 9% |
| Researcher | 40 | 7% |
| Other | 26 | 5% |
| Other | 65 | 12% |
| Unknown | 112 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 95 | 18% |
| Medicine and Dentistry | 59 | 11% |
| Biochemistry, Genetics and Molecular Biology | 44 | 8% |
| Sports and Recreations | 43 | 8% |
| Psychology | 42 | 8% |
| Other | 132 | 25% |
| Unknown | 123 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 455. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 March 2024.
All research outputs
#62,048
of 25,884,216 outputs
Outputs from Psychopharmacology
#13
of 5,371 outputs
Outputs of similar age
#125
of 107,105 outputs
Outputs of similar age from Psychopharmacology
#1
of 32 outputs
Altmetric has tracked 25,884,216 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,371 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 107,105 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.