| Title |
Activity of the hypothalamus–pituitary–interrenal axis (HPI axis) and immune response in carp lines with different susceptibility to disease
|
|---|---|
| Published in |
Fish Physiology and Biochemistry, June 2015
|
| DOI | 10.1007/s10695-015-0084-3 |
| Pubmed ID | |
| Authors |
L. Pijanowski, P. Jurecka, I. Irnazarow, M. Kepka, E. Szwejser, B. M. L. Verburg-van Kemenade, M. Chadzinska |
| Abstract |
The stress response transmitted by the HPA axis is one of the best examples of neuroendocrine-immune interactions that are critical for survival. Analogous to the situation in mammals, the stress response in fish is characterized by the activation of the hypothalamo-pituitary-interrenal axis (HPI). Effects of cortisol on the fish immune system comply with findings in mammals and suggest that the differences in sensitivity to stress will influence the immune response and as a consequence of survival. Therefore, we studied the stress response and its immunity-related effects in four different carp lines (R3, R3xR8, K and R2) that display a differential pathogen susceptibility. Previous studies indicate that R3xR8 and R3 carp are susceptible to bacterial and parasite infection, while R2 and K are relatively resistant to infection. Interestingly, the most striking effect of stress on leukocyte composition and activity was observed in the pathogen-resistant K carp, even though no robust changes in gene expression of stress-involved factors were observed. In contrast, R3 carp showed no spectacular stress-induced changes in their immunological parameters with concurrent significant activation of the HPI axis. Upon stress, the R3 carp showed up-regulation of crf, pomc and gr2 gene expression in the hypothalamus. Furthermore in R3 carp, at all levels of the HPI axis, stress induced the highest up-regulation of il-1β gene expression. Although we are aware of the complexity of the interactions between stress and pathogen susceptibility and of the risk of interpretation based on correlations, it is noteworthy that the fish more susceptible to infection also exhibited the highest response to stress. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 1% |
| Unknown | 75 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 17% |
| Student > Master | 13 | 17% |
| Student > Bachelor | 10 | 13% |
| Researcher | 6 | 8% |
| Student > Doctoral Student | 4 | 5% |
| Other | 12 | 16% |
| Unknown | 18 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 23 | 30% |
| Biochemistry, Genetics and Molecular Biology | 8 | 11% |
| Environmental Science | 6 | 8% |
| Immunology and Microbiology | 5 | 7% |
| Veterinary Science and Veterinary Medicine | 3 | 4% |
| Other | 9 | 12% |
| Unknown | 22 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 June 2015.
All research outputs
#14,227,016
of 22,808,725 outputs
Outputs from Fish Physiology and Biochemistry
#193
of 862 outputs
Outputs of similar age
#138,486
of 267,109 outputs
Outputs of similar age from Fish Physiology and Biochemistry
#3
of 16 outputs
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