Title |
Genomic profiling of glioblastoma: convergence of fundamental biologic tenets and novel insights
|
---|---|
Published in |
Journal of Neuro-Oncology, October 2011
|
DOI | 10.1007/s11060-011-0714-2 |
Pubmed ID | |
Authors |
Kimberly Ng, Ryan Kim, Santosh Kesari, Bob Carter, Clark C. Chen |
Abstract |
With advances in genomic profiling and sequencing technology, we are beginning to understand the landscape of the genetic events that accumulated during the neoplastic process. The insights gleamed from these genomic profiling studies with regards to glioblastoma etiology has been particularly satisfying because it cemented the clinical pertinence of major concepts in cancer biology-concepts developed over the past three decades. This article will review how the glioblastoma genomic data set serves as an illustrative platform for the concepts put forward by Hanahan and Weinberg on the cancer phenotype. The picture emerging suggests that most glioblastomas evolve along a multitude of pathways rather than a single defined pathway. In this context, the article will further provide a discussion of the subtypes of glioblastoma as they relate to key principles of developmental neurobiology. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 2 | 5% |
Netherlands | 1 | 2% |
United Kingdom | 1 | 2% |
Unknown | 40 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 23% |
Student > Master | 6 | 14% |
Professor > Associate Professor | 6 | 14% |
Researcher | 5 | 11% |
Professor | 4 | 9% |
Other | 8 | 18% |
Unknown | 5 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 19 | 43% |
Medicine and Dentistry | 14 | 32% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Neuroscience | 1 | 2% |
Unknown | 8 | 18% |