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Mendeley readers
Attention Score in Context
| Title |
THE UBIQUITIN SYSTEM
|
|---|---|
| Published in |
Annual Review of Biochemistry, June 1998
|
| DOI | 10.1146/annurev.biochem.67.1.425 |
| Pubmed ID | |
| Authors |
Avram Hershko, Aaron Ciechanover |
| Abstract |
The selective degradation of many short-lived proteins in eukaryotic cells is carried out by the ubiquitin system. In this pathway, proteins are targeted for degradation by covalent ligation to ubiquitin, a highly conserved small protein. Ubiquitin-mediated degradation of regulatory proteins plays important roles in the control of numerous processes, including cell-cycle progression, signal transduction, transcriptional regulation, receptor down-regulation, and endocytosis. The ubiquitin system has been implicated in the immune response, development, and programmed cell death. Abnormalities in ubiquitin-mediated processes have been shown to cause pathological conditions, including malignant transformation. In this review we discuss recent information on functions and mechanisms of the ubiquitin system. Since the selectivity of protein degradation is determined mainly at the stage of ligation to ubiquitin, special attention is focused on what we know, and would like to know, about the mode of action of ubiquitin-protein ligation systems and about signals in proteins recognized by these systems. |
Mendeley readers
The data shown below were compiled from readership statistics for 2,824 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 20 | <1% |
| Germany | 14 | <1% |
| United Kingdom | 12 | <1% |
| France | 9 | <1% |
| Spain | 6 | <1% |
| Brazil | 5 | <1% |
| Canada | 4 | <1% |
| Italy | 3 | <1% |
| Switzerland | 3 | <1% |
| Other | 25 | <1% |
| Unknown | 2723 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 681 | 24% |
| Student > Master | 411 | 15% |
| Student > Bachelor | 395 | 14% |
| Researcher | 355 | 13% |
| Student > Doctoral Student | 123 | 4% |
| Other | 327 | 12% |
| Unknown | 532 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 975 | 35% |
| Biochemistry, Genetics and Molecular Biology | 735 | 26% |
| Chemistry | 152 | 5% |
| Medicine and Dentistry | 145 | 5% |
| Neuroscience | 60 | 2% |
| Other | 184 | 7% |
| Unknown | 573 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 September 2023.
All research outputs
#2,378,632
of 25,837,817 outputs
Outputs from Annual Review of Biochemistry
#157
of 1,367 outputs
Outputs of similar age
#1,191
of 34,011 outputs
Outputs of similar age from Annual Review of Biochemistry
#3
of 26 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,367 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.4. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 34,011 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.