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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Differential hypoxic regulation of the microRNA-146a/CXCR4 pathway in normal and leukemic monocytic cells: impact on response to chemotherapy
|
|---|---|
| Published in |
Hematology Journal, June 2015
|
| DOI | 10.3324/haematol.2014.120295 |
| Pubmed ID | |
| Authors |
Isabella Spinello, Maria Teresa Quaranta, Rosa Paolillo, Elvira Pelosi, Anna Maria Cerio, Ernestina Saulle, Francesco Lo Coco, Ugo Testa, Catherine Labbaye |
| Abstract |
High expression of the chemokine receptor 4, CXCR4, associated to negative prognosis in acute myeloid leukemia, is related to hypoxia. Because CXCR4 expression is under the posttranscriptional control of microRNA-146a in normal and leukemic monocytic cells, we first investigated the impact of hypoxia on microRNA-146a and CXCR4 expression during monocytopoiesis and in acute monocytic leukemia. Then, we analyzed the effects of hypoxia on drug sensitivity of CXCR4-expressing leukemic cells. We reported that microRNA-146a is a target of hypoxia-inducible factors (HIFs)-1alpha or -2alpha in relation to the stage of monocytopoiesis and the level of hypoxia, and demonstrated the regulation of the microRNA-146a/CXCR4 pathway by hypoxia in monocytes derived from CD34+ cells. Then, in myeloid leukemic cell lines, hypoxia-mediated control of microRNA-146a/CXCR4 pathway depends only on the capacity of hypoxia-inducible factor-1alpha to upregulate microRNA-146a, which in turn decreases CXCR4 expression. However, at variance with normal monocytic cells and leukemic cell lines, in acute monocytic leukemia overexpressing CXCR4, hypoxia upmodulates microRNA-146a but fails to downmodulate CXCR4 expression. We then investigated the effect of hypoxia on the response of leukemic cells to chemotherapy treatment performed alone or in combination with stromal-derived factor-1alpha. We found that hypoxia increases stromal-derived factor-1alpha-induced survival of leukemic cells by decreasing their sensitivity to anti-leukemic drugs. Altogether, our results demonstrate that hypoxia-mediated regulation of microRNA-146a that controls CXCR4 expression in monocytic cells is lost in acute monocytic leukemia, thus contributing to maintain CXCR4 overexpression and their protection from anti-leukemic drugs in the hypoxic bone marrow microenvironment. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 22 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 18% |
| Student > Master | 4 | 18% |
| Other | 3 | 14% |
| Student > Bachelor | 2 | 9% |
| Researcher | 2 | 9% |
| Other | 7 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 8 | 36% |
| Medicine and Dentistry | 4 | 18% |
| Agricultural and Biological Sciences | 2 | 9% |
| Immunology and Microbiology | 2 | 9% |
| Nursing and Health Professions | 1 | 5% |
| Other | 2 | 9% |
| Unknown | 3 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 June 2015.
All research outputs
#19,944,091
of 25,373,627 outputs
Outputs from Hematology Journal
#3,321
of 4,083 outputs
Outputs of similar age
#192,810
of 281,071 outputs
Outputs of similar age from Hematology Journal
#26
of 41 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,083 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 281,071 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.