| Title |
Effects of combined physical exercise training on DNA damage and repair capacity: role of oxidative stress changes
|
|---|---|
| Published in |
GeroScience, June 2015
|
| DOI | 10.1007/s11357-015-9799-4 |
| Pubmed ID | |
| Authors |
Jorge Pinto Soares, Amélia M. Silva, Maria Manuel Oliveira, Francisco Peixoto, Isabel Gaivão, Maria Paula Mota |
| Abstract |
Regular physical exercise has been shown to be one of the most important lifestyle influences on improving functional performance, decreasing morbidity and all causes of mortality among older people. However, it is known that acute physical exercise may induce an increase in oxidative stress and oxidative damage in several structures, including DNA. Considering this, the purpose of this study was to identify the effects of 16 weeks of combined physical exercise in DNA damage and repair capacity in lymphocytes. In addition, we aimed to investigate the role of oxidative stress involved in those changes. Fifty-seven healthy men (40 to 74 years) were enrolled in this study. The sample was divided into two groups: the experimental group (EG), composed of 31 individuals, submitted to 16 weeks of combined physical exercise training; and the control group (CG), composed of 26 individuals, who did not undergo any specifically orientated physical activity. We observed an improvement of overall physical performance in the EG, after the physical exercise training. A significant decrease in DNA strand breaks and FPG-sensitive sites was found after the physical exercise training, with no significant changes in 8-oxoguanine DNA glycosylase enzyme activity. An increase was observed in antioxidant activity, and a decrease was found in lipid peroxidation levels after physical exercise training. These results suggest that physical exercise training induces protective effects against DNA damage in lymphocytes possibly related to the increase in antioxidant capacity. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 33% |
| Bosnia and Herzegovina | 1 | 17% |
| Australia | 1 | 17% |
| United Kingdom | 1 | 17% |
| Unknown | 1 | 17% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 17% |
| Scientists | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 162 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 162 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 33 | 20% |
| Student > Ph. D. Student | 21 | 13% |
| Student > Bachelor | 20 | 12% |
| Researcher | 14 | 9% |
| Student > Postgraduate | 10 | 6% |
| Other | 26 | 16% |
| Unknown | 38 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Sports and Recreations | 29 | 18% |
| Biochemistry, Genetics and Molecular Biology | 23 | 14% |
| Medicine and Dentistry | 21 | 13% |
| Agricultural and Biological Sciences | 14 | 9% |
| Nursing and Health Professions | 12 | 7% |
| Other | 18 | 11% |
| Unknown | 45 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 July 2020.
All research outputs
#7,714,335
of 25,373,627 outputs
Outputs from GeroScience
#796
of 1,594 outputs
Outputs of similar age
#84,898
of 280,810 outputs
Outputs of similar age from GeroScience
#15
of 29 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 1,594 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.0. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,810 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.