Title |
A synthetic cannabinoid FDU-NNEI, two 2H-indazole isomers of synthetic cannabinoids AB-CHMINACA and NNEI indazole analog (MN-18), a phenethylamine derivative N–OH-EDMA, and a cathinone derivative dimethoxy-α-PHP, newly identified in illegal products
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Published in |
Forensic Toxicology, February 2015
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DOI | 10.1007/s11419-015-0268-7 |
Pubmed ID | |
Authors |
Nahoko Uchiyama, Yoshihiko Shimokawa, Ruri Kikura-Hanajiri, Yosuke Demizu, Yukihiro Goda, Takashi Hakamatsuka |
Abstract |
Six new psychoactive substances were identified together with two other substances (compounds 1-8) in illegal products by our ongoing survey in Japan between January and July 2014. A new synthetic cannabinoid, FDU-NNEI [1-(4-fluorobenzyl)-N-(naphthalen-1-yl)-1H-indole-3-carboxamide, 2], was detected with the newly distributed synthetic cannabinoid FDU-PB-22 (1). Two 2H-indazole isomers of synthetic cannabinoids, AB-CHMINACA 2H-indazole analog (3) and NNEI 2H-indazole analog (4), were newly identified with 1H-indazoles [AB-CHMINACA and NNEI indazole analog (MN-18)]. In addition, 2-methylpropyl N-(naphthalen-1-yl) carbamate (5) and isobutyl 1-pentyl-1H-indazole-3-carboxylate (6) were detected in illegal products. Compound 6 is considered to be a by-product of the preparation of NNEI indazole analog from compound 5 and 1-pentyl-1H-indazole. A phenethylamine derivative, N-OH-EDMA [N-hydroxy-3,4-ethylenedioxy-N-methylamphetamine, 7], and a cathinone derivative, dimethoxy-α-PHP (dimethoxy-α-pyrrolidinohexanophenone, 8), were newly identified in illegal products. Among them, compounds 1 and 8 have been controlled as designated substances (Shitei-Yakubutsu) under the Pharmaceutical Affairs Law in Japan since August and November 2014, respectively. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Japan | 2 | 50% |
United Kingdom | 1 | 25% |
United States | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 5% |
Spain | 1 | 2% |
Unknown | 39 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 29% |
Student > Bachelor | 8 | 19% |
Student > Ph. D. Student | 4 | 10% |
Other | 3 | 7% |
Student > Master | 3 | 7% |
Other | 6 | 14% |
Unknown | 6 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 13 | 31% |
Agricultural and Biological Sciences | 6 | 14% |
Biochemistry, Genetics and Molecular Biology | 3 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 7% |
Medicine and Dentistry | 2 | 5% |
Other | 4 | 10% |
Unknown | 11 | 26% |