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Mendeley readers
Attention Score in Context
| Title |
Synthesis of novel spirostanic saponins and their cytotoxic activity
|
|---|---|
| Published in |
Bioorganic & Medicinal Chemistry, November 2007
|
| DOI | 10.1016/j.bmc.2007.10.089 |
| Pubmed ID | |
| Authors |
Juan C. Hernández, Francisco León, Ignacio Brouard, Fernando Torres, Sara Rubio, José Quintana, Francisco Estévez, Jaime Bermejo |
| Abstract |
This study was carried out to assess the cytotoxicity of several new synthetic steroidal saponins against the human myeloid leukemia cell lines (HL-60 and U937) and against human melanoma cells (SK-MEL-1). Several diosgenyl glycosides analyzed showed strong cell growth inhibition which was associated with alterations in cell cycle progression and induction of apoptosis. Studies of cytochrome c release and caspase-9 activation suggest a main role of the intrinsic pathway of apoptosis in the mechanism of cytotoxicity caused by this kind of compounds. |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Indonesia | 1 | 4% |
| Spain | 1 | 4% |
| Israel | 1 | 4% |
| Unknown | 20 | 87% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 26% |
| Student > Ph. D. Student | 5 | 22% |
| Student > Doctoral Student | 3 | 13% |
| Professor | 1 | 4% |
| Professor > Associate Professor | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 7 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 10 | 43% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 9% |
| Arts and Humanities | 1 | 4% |
| Agricultural and Biological Sciences | 1 | 4% |
| Biochemistry, Genetics and Molecular Biology | 1 | 4% |
| Other | 2 | 9% |
| Unknown | 6 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 February 2021.
All research outputs
#2,329,745
of 25,373,627 outputs
Outputs from Bioorganic & Medicinal Chemistry
#102
of 7,493 outputs
Outputs of similar age
#5,425
of 90,334 outputs
Outputs of similar age from Bioorganic & Medicinal Chemistry
#2
of 106 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,493 research outputs from this source. They receive a mean Attention Score of 4.8. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 90,334 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 106 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.