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Sex differences in brain plasticity: a new hypothesis for sex ratio bias in autism

Overview of attention for article published in Molecular Autism, June 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (58th percentile)

Mentioned by

blogs
2 blogs
twitter
17 X users
facebook
1 Facebook page
googleplus
1 Google+ user

Citations

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71 Dimensions

Readers on

mendeley
99 Mendeley
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Title
Sex differences in brain plasticity: a new hypothesis for sex ratio bias in autism
Published in
Molecular Autism, June 2015
DOI 10.1186/s13229-015-0024-1
Pubmed ID
Authors

Laurent Mottron, Pauline Duret, Sophia Mueller, Robert D Moore, Baudouin Forgeot d’Arc, Sebastien Jacquemont, Lan Xiong

Abstract

Several observations support the hypothesis that differences in synaptic and regional cerebral plasticity between the sexes account for the high ratio of males to females in autism. First, males are more susceptible than females to perturbations in genes involved in synaptic plasticity. Second, sex-related differences in non-autistic brain structure and function are observed in highly variable regions, namely, the heteromodal associative cortices, and overlap with structural particularities and enhanced activity of perceptual associative regions in autistic individuals. Finally, functional cortical reallocations following brain lesions in non-autistic adults (for example, traumatic brain injury, multiple sclerosis) are sex-dependent. Interactions between genetic sex and hormones may therefore result in higher synaptic and consecutively regional plasticity in perceptual brain areas in males than in females. The onset of autism may largely involve mutations altering synaptic plasticity that create a plastic reaction affecting the most variable and sexually dimorphic brain regions. The sex ratio bias in autism may arise because males have a lower threshold than females for the development of this plastic reaction following a genetic or environmental event.

X Demographics

X Demographics

The data shown below were collected from the profiles of 17 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 99 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 15%
Student > Master 10 10%
Student > Bachelor 10 10%
Researcher 9 9%
Student > Doctoral Student 3 3%
Other 12 12%
Unknown 40 40%
Readers by discipline Count As %
Psychology 13 13%
Neuroscience 12 12%
Medicine and Dentistry 9 9%
Biochemistry, Genetics and Molecular Biology 8 8%
Agricultural and Biological Sciences 3 3%
Other 11 11%
Unknown 43 43%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 April 2018.
All research outputs
#1,546,794
of 25,218,929 outputs
Outputs from Molecular Autism
#155
of 717 outputs
Outputs of similar age
#19,080
of 273,087 outputs
Outputs of similar age from Molecular Autism
#11
of 24 outputs
Altmetric has tracked 25,218,929 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 717 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.1. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 273,087 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.