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Chronic low back pain: a mini-review on pharmacological management and pathophysiological insights from clinical and pre-clinical data

Overview of attention for article published in Inflammopharmacology, May 2018
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  • Good Attention Score compared to outputs of the same age and source (66th percentile)

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Title
Chronic low back pain: a mini-review on pharmacological management and pathophysiological insights from clinical and pre-clinical data
Published in
Inflammopharmacology, May 2018
DOI 10.1007/s10787-018-0493-x
Pubmed ID
Authors

Thomas S. W. Park, Andy Kuo, Maree T. Smith

Abstract

Globally, low back pain (LBP) is one of the most common health problems affecting humans. The lifetime prevalence of non-specific LBP is approximately 84%, with the chronic prevalence at about 23%. Chronic LBP in humans is defined as LBP that persists for more than 12 weeks without a significant pain improvement. Although there are numerous evidence-based guidelines on the management of acute LBP, this is not the case for chronic LBP, which is regarded as particularly difficult to treat. Research aimed at discovering new drug treatments for alleviation of chronic mechanical LBP is lacking due to the paucity of knowledge on the pathobiology of this condition, despite its high morbidity in the affected adult population. For a debilitating condition such as chronic LBP, it is necessary to assess the sustained effects of pharmacotherapy of various agents spanning months to years. Although many rodent models of mechanical LBP have been developed to mimic the human condition, some of the major shortcomings of many of these models are (1) the presence of a concurrent neuropathic component that develops secondary to posterior intervertebral disc puncture, (2) severe model phenotype, and/or (3) use of behavioural endpoints that have yet to be validated for pain. Hence, there is a great, unmet need for research aimed at discovering new biological targets in rodent models of chronic mechanical LBP for use in drug discovery programs as a means to potentially produce new highly effective and well-tolerated analgesic agents to improve relief of chronic LBP. On a cautionary note, it must be borne in mind that because humans and rats display orthograde and pronograde postures, respectively, the different mechanical forces on their spines add to the difficulty in translation of promising rodent data to humans.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 51 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 12%
Researcher 5 10%
Student > Master 5 10%
Student > Bachelor 5 10%
Student > Postgraduate 3 6%
Other 8 16%
Unknown 19 37%
Readers by discipline Count As %
Medicine and Dentistry 9 18%
Biochemistry, Genetics and Molecular Biology 4 8%
Nursing and Health Professions 4 8%
Psychology 3 6%
Neuroscience 2 4%
Other 8 16%
Unknown 21 41%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 May 2018.
All research outputs
#15,509,788
of 23,049,027 outputs
Outputs from Inflammopharmacology
#321
of 544 outputs
Outputs of similar age
#207,419
of 325,569 outputs
Outputs of similar age from Inflammopharmacology
#7
of 21 outputs
Altmetric has tracked 23,049,027 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 544 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 325,569 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.