| Title |
Sugar intake is associated with progression from islet autoimmunity to type 1 diabetes: the Diabetes Autoimmunity Study in the Young
|
|---|---|
| Published in |
Diabetologia, June 2015
|
| DOI | 10.1007/s00125-015-3657-x |
| Pubmed ID | |
| Authors |
Molly M. Lamb, Brittni Frederiksen, Jennifer A. Seifert, Miranda Kroehl, Marian Rewers, Jill M. Norris |
| Abstract |
Dietary sugar intake may increase insulin production, stress the beta cells and increase the risk for islet autoimmunity (IA) and subsequent type 1 diabetes. Since 1993, the Diabetes Autoimmunity Study in the Young (DAISY) has followed children at increased genetic risk for type 1 diabetes for the development of IA (autoantibodies to insulin, GAD or protein tyrosine phosphatase-like protein [IA2] twice or more in succession) and progression to type 1 diabetes. Information on intake of fructose, sucrose, total sugars, sugar-sweetened beverages, beverages with non-nutritive sweetener and juice was collected prospectively throughout childhood via food frequency questionnaires (FFQs). We examined diet records for 1,893 children (mean age at last follow-up 10.2 years); 142 developed IA and 42 progressed to type 1 diabetes. HLA genotype was dichotomised as high risk (HLA-DR3/4,DQB1*0302) or not. All Cox regression models were adjusted for total energy, FFQ type, type 1 diabetes family history, HLA genotype and ethnicity. In children with IA, progression to type 1 diabetes was significantly associated with intake of total sugars (HR 1.75, 95% CI 1.07-2.85). Progression to type 1 diabetes was also associated with increased intake of sugar-sweetened beverages in those with the high-risk HLA genotype (HR 1.84, 95% CI 1.25-2.71), but not in children without it (interaction p value = 0.02). No sugar variables were associated with IA risk. Sugar intake may exacerbate the later stage of type 1 diabetes development; sugar-sweetened beverages may be especially detrimental to children with the highest genetic risk of developing type 1 diabetes. |
X Demographics
The data shown below were collected from the profiles of 140 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 18 | 13% |
| United Kingdom | 16 | 11% |
| Spain | 11 | 8% |
| Australia | 8 | 6% |
| South Africa | 6 | 4% |
| Canada | 5 | 4% |
| Brazil | 3 | 2% |
| Sweden | 2 | 1% |
| India | 2 | 1% |
| Other | 9 | 6% |
| Unknown | 60 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 98 | 70% |
| Practitioners (doctors, other healthcare professionals) | 23 | 16% |
| Scientists | 17 | 12% |
| Science communicators (journalists, bloggers, editors) | 2 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | <1% |
| Unknown | 108 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 17 | 16% |
| Student > Master | 13 | 12% |
| Researcher | 10 | 9% |
| Student > Ph. D. Student | 10 | 9% |
| Student > Postgraduate | 7 | 6% |
| Other | 20 | 18% |
| Unknown | 32 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 30 | 28% |
| Nursing and Health Professions | 11 | 10% |
| Agricultural and Biological Sciences | 10 | 9% |
| Biochemistry, Genetics and Molecular Biology | 6 | 6% |
| Social Sciences | 4 | 4% |
| Other | 11 | 10% |
| Unknown | 37 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 276. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 November 2023.
All research outputs
#131,856
of 25,774,185 outputs
Outputs from Diabetologia
#86
of 5,381 outputs
Outputs of similar age
#1,286
of 281,062 outputs
Outputs of similar age from Diabetologia
#1
of 76 outputs
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