| Title |
Dioxin: a review of its environmental effects and its aryl hydrocarbon receptor biology
|
|---|---|
| Published in |
Journal of Comparative Physiology B, April 2005
|
| DOI | 10.1007/s00360-005-0483-3 |
| Pubmed ID | |
| Authors |
Prabir K. Mandal |
| Abstract |
A highly persistent trace environmental contaminant and one of the most potent toxicants known is dioxin (2,3,7,8-tetrachlorodibenzo-para-dioxin or TCDD). TCDD induces a broad spectrum of biological responses, including induction of cytochrome P-450 1A1 (CYP1A1), disruption of normal hormone signaling pathways, reproductive and developmental defects, immunotoxicity, liver damage, wasting syndrome, and cancer. Its classification was upgraded from "possible human carcinogen" (group 2B) to "human carcinogen" (group 1) by the International Agency for Research on Cancer (IARC) in 1997. Exposure to TCDD may also cause changes in sex ratio, and tumor promotion in other animals. Because of the growing public and scientific concern, toxicological studies have been initiated to analyze the short- and long-term effects of dioxin. TCDD brings about a wide variety of toxic and biochemical effects via aryl hydrocarbon receptor (AhR)-mediated signaling pathways. Essential steps in this adaptive mechanism include AhR binding of ligand in the cytoplasm of cells associated with two molecules of chaperone heatshock protein (Hsp90) and AhR interactive protein, translocation of the receptor to the nucleus, dimerization with the Ah receptor nuclear translocator, and binding of this heterodimeric transcription factor (present in CYP1A) to dioxin-responsive elements upstream of promoters that regulate the expression of genes involved in xenobiotic metabolism. |
Mendeley readers
The data shown below were compiled from readership statistics for 323 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 1% |
| Germany | 1 | <1% |
| Netherlands | 1 | <1% |
| Portugal | 1 | <1% |
| Australia | 1 | <1% |
| Sweden | 1 | <1% |
| Finland | 1 | <1% |
| Italy | 1 | <1% |
| United Kingdom | 1 | <1% |
| Other | 3 | <1% |
| Unknown | 308 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 64 | 20% |
| Student > Bachelor | 62 | 19% |
| Student > Master | 48 | 15% |
| Researcher | 35 | 11% |
| Student > Doctoral Student | 14 | 4% |
| Other | 43 | 13% |
| Unknown | 57 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 78 | 24% |
| Environmental Science | 44 | 14% |
| Biochemistry, Genetics and Molecular Biology | 35 | 11% |
| Medicine and Dentistry | 31 | 10% |
| Chemistry | 12 | 4% |
| Other | 55 | 17% |
| Unknown | 68 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 September 2021.
All research outputs
#1,774,929
of 26,017,215 outputs
Outputs from Journal of Comparative Physiology B
#27
of 850 outputs
Outputs of similar age
#2,670
of 76,449 outputs
Outputs of similar age from Journal of Comparative Physiology B
#1
of 5 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 850 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 76,449 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them