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Identification of a Missense Mutation in the Factor VIII Gene of a Mild Hemophiliac

Overview of attention for article published in Science, June 1986
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (75th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (58th percentile)

Mentioned by

patent
3 patents

Citations

dimensions_citation
86 Dimensions

Readers on

mendeley
11 Mendeley
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Title
Identification of a Missense Mutation in the Factor VIII Gene of a Mild Hemophiliac
Published in
Science, June 1986
DOI 10.1126/science.3012775
Pubmed ID
Authors

Jane Gitschier, William I. Wood, Marc A. Shuman, Richard M. Lawn

Abstract

DNA probes derived from the cloned factor VIII gene can be used to detect mutations in the factor VIII gene of hemophiliacs. DNA hybridization analysis led to the identification of two contrasting point mutations in the same codon. In a severe hemophiliac with no detectable factor VIII activity, the normal arginine codon (number 2307) is converted to a stop codon, while in a mild hemophiliac with 10 percent of normal activity, this same codon is converted to glutamine.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 18%
Student > Doctoral Student 1 9%
Student > Bachelor 1 9%
Lecturer > Senior Lecturer 1 9%
Professor 1 9%
Other 3 27%
Unknown 2 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 27%
Medicine and Dentistry 2 18%
Computer Science 1 9%
Nursing and Health Professions 1 9%
Economics, Econometrics and Finance 1 9%
Other 1 9%
Unknown 2 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 November 2004.
All research outputs
#4,764,253
of 23,050,116 outputs
Outputs from Science
#39,432
of 78,175 outputs
Outputs of similar age
#1,234
of 11,017 outputs
Outputs of similar age from Science
#45
of 139 outputs
Altmetric has tracked 23,050,116 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 78,175 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 62.5. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 11,017 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 139 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.