| Title |
Dirty-appearing white matter in multiple sclerosis
|
|---|---|
| Published in |
Journal of Neurology, September 2008
|
| DOI | 10.1007/s00415-008-0002-z |
| Pubmed ID | |
| Authors |
G. R. W. Moore, C. Laule, A. MacKay, E. Leung, D. K. B. Li, G. Zhao, A. L. Traboulsee, D. W. Paty |
| Abstract |
"Dirty-appearing white matter" (DAWM) in multiple sclerosis (MS) is defined as a region(s) with ill-defined borders of intermediate signal intensity between that of normal-appearing white matter (NAWM) and that of plaque on T(2)-weighted and proton density imaging. To delineate the histopathology of DAWM, four formalin-fixed cerebral hemisphere slices of three MS patients with DAWM were scanned with T(2)- weighted and proton density sequences. The myelin water fraction (MWF) was obtained by expressing the short T(2) component as a fraction of the total T(2) distribution. Hemispheric sections were then stained with Luxol fast blue (LFB) for myelin phospholipids, for myelin basic protein (MBP) and 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNP) for myelin; Bielschowsky silver impregnation for axons; and for glial fibrillary acidic protein (GFAP) for astrocytes. Compared to NAWM, DAWM showed reduction in MWF, corresponding to a reduction of LFB staining. DAWM also showed reduced Bielschowsky staining. Quantitatively, the change in MWF in DAWM most consistently correlated with the change in LFB staining. The findings of this preliminary study suggest that DAWM is characterized by loss of myelin phospholipids, detected by the short T(2) component, and axonal reduction. |
Mendeley readers
The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Canada | 1 | 2% |
| Unknown | 63 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 22% |
| Student > Ph. D. Student | 12 | 18% |
| Other | 6 | 9% |
| Student > Doctoral Student | 6 | 9% |
| Professor > Associate Professor | 6 | 9% |
| Other | 17 | 26% |
| Unknown | 4 | 6% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 31% |
| Neuroscience | 14 | 22% |
| Agricultural and Biological Sciences | 9 | 14% |
| Engineering | 4 | 6% |
| Physics and Astronomy | 4 | 6% |
| Other | 7 | 11% |
| Unknown | 7 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 February 2015.
All research outputs
#7,461,241
of 22,811,321 outputs
Outputs from Journal of Neurology
#1,775
of 4,475 outputs
Outputs of similar age
#31,589
of 87,895 outputs
Outputs of similar age from Journal of Neurology
#6
of 20 outputs
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