Title |
Omega-3 fatty acids and risk of cognitive decline in the elderly: a meta-analysis of randomized controlled trials
|
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Published in |
Aging Clinical and Experimental Research, May 2015
|
DOI | 10.1007/s40520-015-0381-9 |
Pubmed ID | |
Authors |
Xiao-Wei Zhang, Wen-Shang Hou, Min Li, Zhen-Yu Tang |
Abstract |
Evidence has demonstrated that omega-3 fatty acids intake may be associated with age-related cognitive decline. However, randomized controlled trials (RCTs) have drawn inconsistent conclusions. We performed a meta-analysis to assess the association between omega-3 fatty acids and risk of cognitive decline in the elderly. A strategic literature search of PubMed, EMBASE, and Cochrane Library (updated to December 2014) was performed. We retrieved six randomized controlled studies as eligible for our meta-analysis. Among these six studies, the duration time ranged from 3 to 40 months. The dose of omega-3 fatty acids (DHA + EPA) ranged from 400 to 1800 mg. The result of our meta-analysis expressed that omega-3 fatty acids statistically decrease the rate of cognitive decline in MMSE score (WMD = 0.15, [0.05, 0.25]; p = 0.003). In conclusion, our meta-analysis indicated that omega-3 fatty acids may help to prevent cognitive decline in the elderly. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 3 | 33% |
United States | 1 | 11% |
India | 1 | 11% |
Turkey | 1 | 11% |
Canada | 1 | 11% |
Unknown | 2 | 22% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 67% |
Practitioners (doctors, other healthcare professionals) | 2 | 22% |
Scientists | 1 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 2 | 2% |
Unknown | 90 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 13% |
Student > Bachelor | 12 | 13% |
Other | 11 | 12% |
Student > Master | 10 | 11% |
Student > Ph. D. Student | 6 | 7% |
Other | 15 | 16% |
Unknown | 26 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 21 | 23% |
Nursing and Health Professions | 12 | 13% |
Agricultural and Biological Sciences | 9 | 10% |
Biochemistry, Genetics and Molecular Biology | 7 | 8% |
Neuroscience | 5 | 5% |
Other | 11 | 12% |
Unknown | 27 | 29% |