| Title |
Endocrine-disrupting chemicals and risk of diabetes: an evidence-based review
|
|---|---|
| Published in |
Diabetologia, May 2018
|
| DOI | 10.1007/s00125-018-4621-3 |
| Pubmed ID | |
| Authors |
P. Monica Lind, Lars Lind |
| Abstract |
The purpose of this study was to review the epidemiological and experimental evidence linking background exposure to a selection of environmental endocrine-disrupting chemicals (EDCs) with diabetes and impaired glucose metabolism. The review summarises the literature on both cross-sectional and prospective studies in humans, as well as experimental in vivo and in vitro studies. The findings were subjected to evidence grading according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) classification. We found >40 cross-sectional and seven prospective studies regarding EDCs and risk of diabetes. Taken together, there is moderate evidence for a relationship between exposure to dichlorodiphenyldichloroethylene (p,p'-DDE), a metabolite of the pesticide dichlorodiphenyltrichloroethane, and diabetes development. Regarding polychlorinated biphenyls (PCBs), it is likely that the rodent models used are not appropriate, and therefore the evidence is poorer than for p,p'-DDE. For other EDCs, such as bisphenol A, phthalates and perfluorinated chemicals, the evidence is scarce, since very few prospective studies exist. Brominated flame retardants do not seem to be associated with a disturbed glucose tolerance. Thus, evidence is accumulating that EDCs might be involved in diabetes development. Best evidence exists for p,p'-DDE. For other chemicals, both prospective studies and supporting animal data are still lacking. |
X Demographics
The data shown below were collected from the profiles of 42 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 19% |
| India | 5 | 12% |
| United Kingdom | 4 | 10% |
| Canada | 2 | 5% |
| Spain | 2 | 5% |
| France | 2 | 5% |
| Singapore | 1 | 2% |
| Finland | 1 | 2% |
| Brazil | 1 | 2% |
| Other | 2 | 5% |
| Unknown | 14 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 23 | 55% |
| Practitioners (doctors, other healthcare professionals) | 9 | 21% |
| Scientists | 8 | 19% |
| Science communicators (journalists, bloggers, editors) | 2 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 161 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 161 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 20 | 12% |
| Student > Ph. D. Student | 17 | 11% |
| Researcher | 16 | 10% |
| Student > Master | 16 | 10% |
| Student > Doctoral Student | 8 | 5% |
| Other | 16 | 10% |
| Unknown | 68 | 42% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 24 | 15% |
| Biochemistry, Genetics and Molecular Biology | 14 | 9% |
| Environmental Science | 10 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 5% |
| Agricultural and Biological Sciences | 7 | 4% |
| Other | 24 | 15% |
| Unknown | 74 | 46% |
Attention Score in Context
This research output has an Altmetric Attention Score of 74. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2023.
All research outputs
#585,427
of 25,540,105 outputs
Outputs from Diabetologia
#290
of 5,360 outputs
Outputs of similar age
#12,957
of 341,426 outputs
Outputs of similar age from Diabetologia
#6
of 59 outputs
Altmetric has tracked 25,540,105 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,360 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.7. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,426 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.