Title |
The human Ago2 MC region does not contain an eIF4E-like mRNA cap binding motif
|
---|---|
Published in |
Biology Direct, January 2009
|
DOI | 10.1186/1745-6150-4-2 |
Pubmed ID | |
Authors |
Lisa N Kinch, Nick V Grishin |
Abstract |
Argonaute (Ago) proteins interact with small regulatory RNAs to mediate gene regulatory pathways. A recent report by Kiriakidou et al. 1 describes an MC sequence region identified in Ago2 that displays similarity to the cap-binding motif in translation initiation factor 4E (eIF4E). In a cap-bound eIF4E structure, two important aromatic residues of the motif stack on either side of a 7-methylguanosine 5'-triphosphate (m7Gppp) base. The corresponding Ago2 aromatic residues (F450 and F505) were hypothesized to perform the same cap-binding function. However, the detected similarity between the MC sequence and the eIF4E cap-binding motif was questionable. |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 2% |
United Kingdom | 1 | 2% |
Argentina | 1 | 2% |
Spain | 1 | 2% |
Japan | 1 | 2% |
Greece | 1 | 2% |
United States | 1 | 2% |
Unknown | 47 | 87% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 20% |
Student > Master | 7 | 13% |
Student > Bachelor | 6 | 11% |
Student > Ph. D. Student | 6 | 11% |
Professor > Associate Professor | 6 | 11% |
Other | 10 | 19% |
Unknown | 8 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 26 | 48% |
Biochemistry, Genetics and Molecular Biology | 14 | 26% |
Chemistry | 3 | 6% |
Neuroscience | 2 | 4% |
Materials Science | 1 | 2% |
Other | 0 | 0% |
Unknown | 8 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 March 2009.
All research outputs
#5,678,373
of 22,655,397 outputs
Outputs from Biology Direct
#210
of 487 outputs
Outputs of similar age
#38,046
of 169,955 outputs
Outputs of similar age from Biology Direct
#14
of 21 outputs
Altmetric has tracked 22,655,397 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 487 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.7. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 169,955 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.