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Number of CpG islands and genes in human and mouse.

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, December 1993
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

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1 X user
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28 patents

Citations

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803 Dimensions

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423 Mendeley
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Title
Number of CpG islands and genes in human and mouse.
Published in
Proceedings of the National Academy of Sciences of the United States of America, December 1993
DOI 10.1073/pnas.90.24.11995
Pubmed ID
Authors

F Antequera, A Bird

Abstract

Estimation of gene number in mammals is difficult due to the high proportion of noncoding DNA within the nucleus. In this study, we provide a direct measurement of the number of genes in human and mouse. We have taken advantage of the fact that many mammalian genes are associated with CpG islands whose distinctive properties allow their physical separation from bulk DNA. Our results suggest that there are approximately 45,000 CpG islands per haploid genome in humans and 37,000 in the mouse. Sequence comparison confirms that about 20% of the human CpG islands are absent from the homologous mouse genes. Analysis of a selection of genes suggests that both human and mouse are losing CpG islands over evolutionary time due to de novo methylation in the germ line followed by CpG loss through mutation. This process appears to be more rapid in rodents. Combining the number of CpG islands with the proportion of island-associated genes, we estimate that the total number of genes per haploid genome is approximately 80,000 in both organisms.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 423 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 4 <1%
United States 4 <1%
United Kingdom 3 <1%
Israel 1 <1%
India 1 <1%
Czechia 1 <1%
Turkey 1 <1%
Mexico 1 <1%
Italy 1 <1%
Other 2 <1%
Unknown 404 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 117 28%
Student > Master 60 14%
Researcher 53 13%
Student > Bachelor 48 11%
Professor 22 5%
Other 73 17%
Unknown 50 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 190 45%
Biochemistry, Genetics and Molecular Biology 103 24%
Medicine and Dentistry 33 8%
Neuroscience 8 2%
Computer Science 5 1%
Other 22 5%
Unknown 62 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 April 2024.
All research outputs
#4,640,360
of 24,622,191 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#44,073
of 101,438 outputs
Outputs of similar age
#5,340
of 73,983 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#89
of 374 outputs
Altmetric has tracked 24,622,191 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 101,438 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 73,983 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 374 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.